Isolation and Genomic Analyses of an Early SARS-CoV-2 Strains from the 2020 Epidemic in Gwangju, South Korea
| العنوان: | Isolation and Genomic Analyses of an Early SARS-CoV-2 Strains from the 2020 Epidemic in Gwangju, South Korea |
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| المؤلفون: | Jung-Wook Park, Mi hyeon Lim, Ji-eun Yoon, Da jeong Hwang, Jin Jong Seo, Jae Keun Chung, Kwang gon Kim, Ji-Eun Lee, Tae Sun Kim, Jong-jin Park, Jin Jeong, Hye Young Kee, Min Ji Kim |
| المصدر: | Journal of Bacteriology and Virology. 51:138-147 |
| بيانات النشر: | The Korean Society for Microbiology and The Korean Society of Virology, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Whole genome sequencing, Genetics, Genetic diversity, Phylogenetic tree, viruses, fungi, Immunology, virus diseases, Gene mutation, Biology, Microbiology, Genome, Virus, body regions, Viral replication, Virology, skin and connective tissue diseases, Clade |
| الوصف: | Since the first identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China in late December 2019, the coronavirus disease 2019 (COVID-19) has spread fast around the world. RNA viruses, including SARS-CoV-2, have higher gene mutations than DNA viruses during virus replication. Variations in SARS-CoV-2 genome could contribute to efficiency of viral spread and severity of COVID-19. In this study, we analyzed the locations of genomic mutations to investigate the genetic diversity among isolates of SARS-CoV-2 in Gwangju. We detected non-synonymous and frameshift mutations in various parts of SARS-CoV-2 genome. The phylogenetic analysis for whole genome showed that SARS-CoV-2 genomes in Gwangju isolates are clustered within clade V and G. Our findings not only provide a glimpse into changes of prevalent virus clades in Gwangju, South Korea, but also support genomic surveillance of SARS-CoV-2 to aid in the development of efficient therapeutic antibodies and vaccines against COVID-19. © This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License. |
| تدمد: | 2093-0429 1598-2467 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::7fe67d739fa6f04484aa8d6ba96751f2 https://doi.org/10.4167/jbv.2021.51.3.138 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........7fe67d739fa6f04484aa8d6ba96751f2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20930429 15982467 |
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