Mechanistic divergence between (4S,7R)-germacra-(1(10)E,5E)-dien-11-ol synthases from Dictyostelium purpureum and Streptomyces coelicolor
| العنوان: | Mechanistic divergence between (4S,7R)-germacra-(1(10)E,5E)-dien-11-ol synthases from Dictyostelium purpureum and Streptomyces coelicolor |
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| المؤلفون: | Houchao Xu, Xinlu Chen, Feng Chen, Tobias G. Köllner, Jan Rinkel, Jeroen S. Dickschat |
| المصدر: | Organic & Biomolecular Chemistry. 19:370-374 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Dictyostelium purpureum, biology, Stereochemistry, Chemistry, Convergent evolution, Organic Chemistry, Streptomyces coelicolor, Physical and Theoretical Chemistry, Geosmin synthase, biology.organism_classification, Biochemistry, Sequence identity |
| الوصف: | The main product of DpTPS9 from the social amoeba Dictyostelium purpureum was identified as (4S,7R)-germacra-(1(10)E,5E)-dien-11-ol that is also known as an intermediate of bacterial geosmin synthase, but the experimentally verified cyclisation mechanisms differ. Together with the low sequence identity this points to convergent evolution. The functionality of selected residues in DpTPS9 was investigated via site-directed mutagenesis experiments. |
| تدمد: | 1477-0539 1477-0520 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::80b00b0bfc55bd4fe95f20d05fac4888 https://doi.org/10.1039/d0ob02361b |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........80b00b0bfc55bd4fe95f20d05fac4888 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770539 14770520 |
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