First known case of paediatric inflammatory bowel disease in a western lowland gorilla may be linked to a familial mutation in the MEFV gene
| العنوان: | First known case of paediatric inflammatory bowel disease in a western lowland gorilla may be linked to a familial mutation in the MEFV gene |
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| المؤلفون: | Bernd Bokemeyer, Stefan Schreiber, Hermann Will, Britt-Sabina Petersen, Stefan Hoby, Marc P. Hoeppner, Andre Franke, Katrin Baumgartner, Ingo Mecklenburg, Christian Wenker |
| المصدر: | Gut. 69:1153-1154 |
| بيانات النشر: | BMJ, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Crohn's disease, Mutation, biology, business.industry, Gastroenterology, Captivity, Disease, medicine.disease, biology.organism_classification, medicine.disease_cause, MEFV, Inflammatory bowel disease, Pyrin domain, 03 medical and health sciences, Western lowland gorilla, 030104 developmental biology, 0302 clinical medicine, Immunology, medicine, 030211 gastroenterology & hepatology, business |
| الوصف: | We read with interest the recent work by Schwerd et al 1 showing yet another example of human monogenic diseases that can present with IBD-like intestinal inflammation. Among the genes and diseases related to these often early onset monogenic IBD cases in humans is also the MEFV gene encoding for pyrin. The DNA sequence of gorillas shows >98% identity to the human genome.2 However, so far, there are only individual case descriptions of severe colitis due to infections3–6 and, to our knowledge, no cases of IBD have been reported in gorillas so far. We here report two closely related female western lowland gorillas living in captivity and showing partly overlapping GI symptoms, following the relocation into new groups in different zoos. The first case Enea (figure 1A) shows the typical clinical signs of a chronic IBD, most likely Crohn’s disease (CD). After a psychological stress situation, the relocation to a new zoo involving minor dietary … |
| تدمد: | 1468-3288 0017-5749 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::815663a3a869399d3e63617c156569bb https://doi.org/10.1136/gutjnl-2019-319051 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........815663a3a869399d3e63617c156569bb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14683288 00175749 |
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