Pyrrolo[2,1-a]isoquinoline scaffold in drug discovery: advances in synthesis and medicinal chemistry
| العنوان: | Pyrrolo[2,1-a]isoquinoline scaffold in drug discovery: advances in synthesis and medicinal chemistry |
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| المؤلفون: | Leonid G. Voskressensky, Maria D. Matveeva, Cosimo Altomare, Rosa Purgatorio |
| المصدر: | Future Medicinal Chemistry. 11:2735-2755 |
| بيانات النشر: | Future Science Ltd, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Pharmacology, Scaffold, 010405 organic chemistry, Chemistry, Drug discovery, Tumor cells, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, Mechanism of action, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, Pharmacophore, medicine.symptom, Isoquinoline |
| الوصف: | Pyrrolo[2,1- a]isoquinoline (PIq) is a nitrogen heterocyclic scaffold of diverse alkaloids endowed with several biological activities, including antiretroviral and antitumor activities. Several 5,6-dihydro-PIq (DHPIq) alkaloids, belonging to the lamellarins’ family, have proved to be cytotoxic to tumor cells, as well as reversers of multidrug resistance. In this review, we provide an overview of the main achievements over the last decade in the synthetic approaches to access libraries of PIq compounds along with a survey, as comprehensive as possible, of bioactivity, mechanism of action, pharmacophore and structure–activity relationships of synthetic analogs of DHPIq-based alkaloids. The focus is mainly on the potential exploitation of the (DH)PIq scaffold in design and development of novel antitumor drugs. |
| تدمد: | 1756-8927 1756-8919 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::82dcd542fe4e890f18bc8a51158113b9 https://doi.org/10.4155/fmc-2019-0136 |
| رقم الأكسشن: | edsair.doi...........82dcd542fe4e890f18bc8a51158113b9 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17568927 17568919 |
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