Macrophage Activation by Micropolyspora faeni Does Not Suppress Anamnestic Pulmonary Immunologic Reactivity
| العنوان: | Macrophage Activation by Micropolyspora faeni Does Not Suppress Anamnestic Pulmonary Immunologic Reactivity |
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| المؤلفون: | M.R. Schuyler, J. Pensky |
| المصدر: | International Archives of Allergy and Immunology. 84:142-148 |
| بيانات النشر: | S. Karger AG, 1987. |
| سنة النشر: | 1987 |
| مصطلحات موضوعية: | Cellular immunity, Lung, biology, Immunology, Serum albumin, General Medicine, Lymphocyte proliferation, medicine.anatomical_structure, Antigen, Alveolar macrophage, biology.protein, medicine, Immunology and Allergy, Bovine serum albumin, Pulmonary alveolus |
| الوصف: | Determinants of lung immunologic response to antigens are not known, but could include alveolar macrophage (AM) activation. We tested the ability of AM activation to modify the anamnestic response by administering bovine serum albumin (BSA) intratracheally, activating AM (by intratracheal Micropolyspora faeni), and then exposing rabbits again to intratracheal BSA. We compared the results from 4 groups of animals: intratracheal administration of either 50 mg M. faeni or normal saline and later administration of either intratracheal or intramuscular BSA. M. faeni administered intratracheally increased the number of AM. These AM were activated (increased phagocytosis of IgG-coated particles). We found no difference in the amount of antibody in either lavage fluid or serum or in antigen-induced pulmonary parenchymal and hilar node lymphocyte proliferation among these 4 groups. |
| تدمد: | 1423-0097 1018-2438 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::833c7eba20e50e9cd785a462f6510f3c https://doi.org/10.1159/000234413 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........833c7eba20e50e9cd785a462f6510f3c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230097 10182438 |
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