Infarction of the papillary muscle is an independent predictor of heart failure, ventricular tachycardia, and consequent mortality
| العنوان: | Infarction of the papillary muscle is an independent predictor of heart failure, ventricular tachycardia, and consequent mortality |
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| المؤلفون: | C Beijnink, S Raessens, J T Ortiz-Perez, V Bodi, L Rodwell, F Valente, M Alamar, V Marcos-Garces, D Lorenzatti, C Rios-Navarro, J Gavara, I Ferreira, J A Barrabes, J Rodriguez Palomares, R Nijveldt |
| المصدر: | European Heart Journal. 43 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine |
| الوصف: | Background Previous studies have assessed the effect of papillary muscle infarction (papMI) as seen with Late Gadolinium Enhancement (LGE) Cardiac Magnetic Resonance imaging (CMR) after ST-segment elevation myocardial infarction (STEMI) on patient prognosis. As these studies delivered inconclusive results due to limited sample size and follow-up, we set out to assess whether STEMI patients with papMI are at an increased risk of cardiovascular mortality, heart failure, and arrhythmic events. Methods This is a 3-center observational study in n=1,055 consecutive STEMI patients who underwent CMR at a median of 6 (4–9) days, with a mean follow-up of 6.0 years (IQR 3.1–9.1 years). Any presence of papMI, be it supero-lateral, infero-medial, or double, was evaluated visually on the LGE images and checked on the matched cine images. The primary outcomes are time to cardiovascular mortality, heart-failure events defined as heart failure death and hospital admission for heart failure, and arrhythmic events, defined as arrhythmic death and ventricular tachycardia (VT). Results PapMI was diagnosed in 351 patients (33%). PapMI is an independent predictor of cardiovascular mortality after correction for clinically relevant parameters such as infarct size and left ventricular ejection fraction (Multivariate Cox Regression Hazard Ratio (HR)=2.46, 95% confidence interval (CI) 1.23–4.92). Secondly, papMI independently predicts the combined endpoints of heart failure death/heart failure (HR=1.72, 95% CI 1.12–2.63) and arrhythmic death/ VT (HR=4.52, 95% CI 2.18–9.36). Conclusions PapMI predicts cardiovascular mortality, arrhythmic death and heart failure. PapMI should be taken into account, especially when conducting new prognosis studies after STEMI and as a stratification factor in studies for secondary prevention of VT and arrhythmic death. Funding Acknowledgement Type of funding sources: Other. |
| تدمد: | 1522-9645 0195-668X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::835a58da479e55c2db9222a042b35f5d https://doi.org/10.1093/eurheartj/ehac544.1177 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........835a58da479e55c2db9222a042b35f5d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229645 0195668X |
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