Diagnosing lung cancer using etoposide microparticles labeled with 99mTc
| العنوان: | Diagnosing lung cancer using etoposide microparticles labeled with 99mTc |
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| المؤلفون: | Cristal Cerqueira-Coutinho, Ralph Santos-Oliveira, Sofia Nascimento dos Santos, Patricia L. B. Araujo, Suyene Rocha Pinto, Roberto Salvi, Eduardo Ricci-Júnior, Emerson Soares Bernardes |
| المصدر: | Artificial Cells, Nanomedicine, and Biotechnology. 46:341-345 |
| بيانات النشر: | Informa UK Limited, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Biomedical Engineering, Pharmaceutical Science, Medicine (miscellaneous), Spleen, 02 engineering and technology, 03 medical and health sciences, 0302 clinical medicine, medicine, Lung cancer, Etoposide, medicine.diagnostic_test, business.industry, Cancer, General Medicine, 021001 nanoscience & nanotechnology, medicine.disease, Tumor site, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Total dose, 0210 nano-technology, business, Nuclear medicine, Technetium-99m, Emission computed tomography, Biotechnology, medicine.drug |
| الوصف: | The diagnosis of lung cancer mostly occurs when the cancer is already in an advanced stage. In this situation, there are few options for the treatment and most of them have few chances of success. In this study, we developed and tested etoposide microparticles as a diagnostic agent for imaging lung cancer at early stages of development. We tested etoposide microparticles labeled with technetium 99m in inducted mice. The results demonstrated that over 10% of the total dose used was uptake by the tumor site. Also, the results showed that the microparticles had a good renal clearance and low uptake by liver and spleen. The data suggest that these micro-radiopharmaceuticals may be used for lung cancer imaging exam, especially single-photo emission computed tomography (SPECT).[Formula: see text]. |
| تدمد: | 2169-141X 2169-1401 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::8506f982c846e8b72cf7d9c0619f2008 https://doi.org/10.1080/21691401.2017.1307848 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........8506f982c846e8b72cf7d9c0619f2008 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 2169141X 21691401 |
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