Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer
| العنوان: | Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer |
|---|---|
| المؤلفون: | Hyekyung Hong, Iain Beehuat Tan, Jae Woong Min, Diether Lambrechts, Hae Ock Lee, Sara Verbandt, Pratyaksha Wirapati, Tae-You Kim, Jung Kyoon Choi, Junbin Qian, Nayoung K.D. Kim, Gert De Hertogh, Minae An, Hakki Emre Etlioglu, Woong-Yang Park, Seok-Hyung Kim, Gunhwan Ko, Valentina Pomella, Hyun Tae Shin, Yong Beom Cho, Woo Yong Lee, Jasper Vanhecke, Shyam Prabhakar, Ben Van den Bosch, Seong Hyeon Yun, Sabine Tejpar, Min Hyeok Jung, Taeseob Lee, Bobby Ranjan, Petros Tsantoulis, Je-Gun Joung, Young Joon Kim, Hye Hyeon Eum, Bram Boeckx, Woosung Chung, Yourae Hong, Hee Cheol Kim |
| المصدر: | Nature Genetics. 52:594-603 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Regulation of gene expression, 0303 health sciences, Stromal cell, Colorectal cancer, medicine.medical_treatment, Immunotherapy, Biology, medicine.disease, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Immune system, Single-cell analysis, Cancer cell, Genetics, Cancer research, medicine, 030217 neurology & neurosurgery, 030304 developmental biology |
| الوصف: | Immunotherapy for metastatic colorectal cancer is effective only for mismatch repair-deficient tumors with high microsatellite instability that demonstrate immune infiltration, suggesting that tumor cells can determine their immune microenvironment. To understand this cross-talk, we analyzed the transcriptome of 91,103 unsorted single cells from 23 Korean and 6 Belgian patients. Cancer cells displayed transcriptional features reminiscent of normal differentiation programs, and genetic alterations that apparently fostered immunosuppressive microenvironments directed by regulatory T cells, myofibroblasts and myeloid cells. Intercellular network reconstruction supported the association between cancer cell signatures and specific stromal or immune cell populations. Our collective view of the cellular landscape and intercellular interactions in colorectal cancer provide mechanistic information for the design of efficient immuno-oncology treatment strategies. |
| تدمد: | 1546-1718 1061-4036 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::856d19004813b6cf37594c8d71e2db7e https://doi.org/10.1038/s41588-020-0636-z |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........856d19004813b6cf37594c8d71e2db7e |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15461718 10614036 |
|---|