Bisphenol A Induces Apoptosis in Liver Cells through Induction of ROS
| العنوان: | Bisphenol A Induces Apoptosis in Liver Cells through Induction of ROS |
|---|---|
| المؤلفون: | Chao Quan, Ansoumane Kourouma, Kedi Yang, Peng Duan, Suqin Qi, Tingting Yu, Yinan Wang |
| المصدر: | Advances in Toxicology. 2015:1-10 |
| بيانات النشر: | Hindawi Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | chemistry.chemical_classification, medicine.medical_specialty, Antioxidant, biology, Chemistry, medicine.medical_treatment, Glutathione peroxidase, General Engineering, Malondialdehyde, medicine.disease_cause, Transaminase, Superoxide dismutase, chemistry.chemical_compound, Endocrinology, Catalase, Internal medicine, Lactate dehydrogenase, medicine, biology.protein, Oxidative stress |
| الوصف: | Oxidative stress mechanisms are involved in hepatotoxicity. The liver is reported to be affected by bisphenol A (BPA) in animals studies and has been also reported to possess hepatic toxicity. This study aimed to examine association between liver health status and the effects of BPA on the antioxidant defense systems and liver biomarkers. BPA (0, 2, 10, and 50 mg/kg) body weight was mixed in corn oil and intraperitoneally administered every forty-eight hours for 30 days in dose-dependent manner. There was no significant difference between the body weight and weight of rat liver in BPA-treated groups and control groups. The study results show that the levels of malondialdehyde (MDA) and hydrogen peroxide (H2O2) increased after exposure to BPA. However, the antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-PX) were significantly (P<0.001,P<0.05, andP<0.001, resp.) decreased at 50 mg/kg dosage. Liver markers activities such as lactate dehydrogenase (LDH), glutamic-oxalacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) were significantly increased, whileγ-glutamyl transferase (γ-GT) activity was decreased. BPA exposure increased activity of liver biomarkers indicating liver hyperactivity. Analysis of the liver section provided essential evidence of liver apoptosis. Moreover, BPA may lead to induced toxic response of liver oxidative system. |
| تدمد: | 2314-7822 2356-6906 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::85c12192f9662dec89efa5d7b3bf2702 https://doi.org/10.1155/2015/901983 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........85c12192f9662dec89efa5d7b3bf2702 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23147822 23566906 |
|---|