ChemInform Abstract: A Copper-Catalyzed Domino Radical Cyclization Route to Benzospiro-indolizidinepyrrolidinones
| العنوان: | ChemInform Abstract: A Copper-Catalyzed Domino Radical Cyclization Route to Benzospiro-indolizidinepyrrolidinones |
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| المؤلفون: | Yves Eeckhout, Wim Hooghe, Viktor V. Zhdankin, Bart D’hondt, Christian V. Stevens, Victor N. Nemykin, Kurt G. R. Masschelein, Ellen Van Meenen |
| المصدر: | ChemInform. 39 |
| بيانات النشر: | Wiley, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Indole test, Stereochemistry, Substituent, chemistry.chemical_element, General Medicine, Copper, Radical cyclization, Medicinal chemistry, Domino, Catalysis, chemistry.chemical_compound, chemistry, Copper catalyzed, Single crystal |
| الوصف: | In this Letter the synthesis of benzospiro-indolizidinepyrrolidinones is described by a domino atom transfer radical cyclization reaction using a copper catalyst. The structure of one of the products was established by single crystal X-ray diffraction. The investigated precursors, bearing a homo allyl substituent on the N -indole, result in a 5- exo - trig , followed by a 6- endo - trig cyclization. When the N -indole is substituted with an allyl group, only the spiro-cyclization occurs. |
| تدمد: | 1522-2667 0931-7597 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::87af8a2d8b29d22841425dd669dd0797 https://doi.org/10.1002/chin.200803111 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........87af8a2d8b29d22841425dd669dd0797 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15222667 09317597 |
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