Cutting Edge: CD49d+ Neutrophils Induce FcεRI Expression on Lung Dendritic Cells in a Mouse Model of Postviral Asthma
| العنوان: | Cutting Edge: CD49d+ Neutrophils Induce FcεRI Expression on Lung Dendritic Cells in a Mouse Model of Postviral Asthma |
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| المؤلفون: | Larry L. Thomas, Michael J. Holtzman, Mitchell H. Grayson, D. A. Riley, S.J. Ehlenbach, R.T. Kitchens, Dorothy S. Cheung |
| المصدر: | The Journal of Immunology. 185:4983-4987 |
| بيانات النشر: | The American Association of Immunologists, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Lung, medicine.diagnostic_test, Immunology, Biology, medicine.disease, CD49d, biology.organism_classification, Sendai virus, respiratory tract diseases, Flow cytometry, Atopy, medicine.anatomical_structure, Downregulation and upregulation, medicine, Immunology and Allergy, Respiratory system, Asthma |
| الوصف: | The increasing prevalence of atopy and asthma remains unexplained but may be due to infection with respiratory viruses. In support of this hypothesis, we showed that experimental asthma after viral infection in mice depended on type I IFN-driven upregulation of FcεRI on conventional dendritic cells (cDCs) in the lung. In this article, we demonstrate that FcεRI expression on lung cDCs depends on an unexpected activity of a CD49d+ subset of polymorphonuclear neutrophils (PMNs) that are found in the lungs of wild-type C57BL6 but not mice deficient in type I IFNR. Expression of FcεRI depends in part on a CD11b-dependent interaction between PMNs and cDCs. This study demonstrates a PMN–cDC interaction in the lung that is necessary for the ability of viral infection to induce atopic disease. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::87f45bae3032fabc023298e09db273d3 https://doi.org/10.4049/jimmunol.1002456 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........87f45bae3032fabc023298e09db273d3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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