Glucosinolates with their Hydrolysis Products from Two Cruciferous Plants with Study of Antidiabetic Activity Based on Molecular Docking
| العنوان: | Glucosinolates with their Hydrolysis Products from Two Cruciferous Plants with Study of Antidiabetic Activity Based on Molecular Docking |
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| المؤلفون: | Suliman A. Alderhami, Khaled A. Abdelshafeek, Walid E. Abdallah, Ahmed A. Elhenawy, AbdulAziz Ali Alomari |
| المصدر: | Biomedical and Pharmacology Journal. 14:2047-2062 |
| بيانات النشر: | Oriental Scientific Publishing Company, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pharmacology |
| الوصف: | Glucosinolates (Gls) are natural bioactive compounds that form metabolites called isothiocyanates (ITC) which have various therapeutic effects. This study aimed to isolate the glucosinolates of Carrichtera annua L.(DC) (CA) and Farsetia aegyptia Turra (FA) belonging to the Crucifereae family. Total Gls were isolated from the aqueous methanolic extract of the plants and further purified using an acidic aluminum oxide column. Some of the obtained Gls were identified via spectroscopic methods (UV, NMR, and MS) and the rest were hydrolyzed by myrosinase to the corresponding isothiocyanates (ITC) for identification by GC/MS. Only one Gls was identified in CA as 4-methylthio-3-butenyl Gls (MTBG) in addition to 6-methyl sulfonylhexyl isothiocyanates (ITC), while 6-methyl sulfonyl-6-hydroxy hexyl ITC, 4-pentenyl ITC, 3-methylthio propyl ITC, 5-hydroxy pentyl ITC and 4-methylsulphinyl butyl ITC were identified in FA. The Gls demonstrated high binding activity to α-glucosidase and amylase, good pharmacokinetic characteristics, and exerted no carcinogenetic effects. |
| تدمد: | 2456-2610 0974-6242 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::89447063407b43b6922aa832a60c79ea https://doi.org/10.13005/bpj/2302 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........89447063407b43b6922aa832a60c79ea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24562610 09746242 |
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