Familial predisposition to cardiovascular disease and death in patients with an out-of-hospital cardiac arrest
| العنوان: | Familial predisposition to cardiovascular disease and death in patients with an out-of-hospital cardiac arrest |
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| المؤلفون: | M Gylling, J Kroll, P E Warming, C M Hansen, F Folke, S M Hansen, L Kober, C Torp-Pedersen, R Garcia, J Tfelt-Hansen, P Weeke |
| المصدر: | Europace. 25 |
| بيانات النشر: | Oxford University Press (OUP), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Physiology (medical), Cardiology and Cardiovascular Medicine |
| الوصف: | Funding Acknowledgements Type of funding sources: Public hospital(s). Main funding source(s): Rigshospitalet Introduction Familial predisposition to cardiovascular disease (CVD) and death among patients with out-of-hospital cardiac arrest (OHCA), is sparsely described in current literature. A higher rate of events in first-degree relatives might imply an increased risk of future cardiac arrest and could provide vital improvements in prevention of sudden cardiac death. Therefore, investigation of CVD and death in family of OHCA-victims is needed. Purpose Determine familial predisposition to CVD and death in patients with OHCA. Methods This study used the nationwide Danish Cardiac Arrest Registry to identify all patients with OHCA (probands) of presumed cardiac origin from 2001-2014 and Results We identified 5,443 probands (75% male, median age 51 years) with 16,260 first-degree relatives; 10,207 parents (48.2% fathers, median age 71 years) and 6,053 full siblings (52.7% brothers, median age 47.2 years). Parents to probands had a higher rate of CVD (27.5% vs. 21.9%), a higher mortality rate (51.4% vs. 38.4%) and death more often caused by CVD (39.9% vs. 34.1%) compared to parents of the background population (p Conclusion Familial predisposition to both cardiovascular disease and death is more prevalent in patients with an out-of-hospital cardiac arrest compared to the background population. These results indicate that, cardiovascular disease and death of first-degree relatives is important risk factors for sudden cardiac arrest in the family. |
| تدمد: | 1532-2092 1099-5129 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::8a37532941abd63c76f85c87f089a75d https://doi.org/10.1093/europace/euad122.286 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........8a37532941abd63c76f85c87f089a75d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15322092 10995129 |
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