| الوصف: |
The trace amines have been implicated in a number of psychiatric and other brain disorders (Davis et al., 1982). It has been suggested that a defect in the metabolism of p-tyramine (p-TA) may underlie a predisposition to and attacks of migraine (Smith et al., 1971; Youdim et al., 1971; Sandler et al., 1974; Glover et al., 1977; Glover et al., 1981; Littlewood et al., 1982;Glover et al., 1983) and depression (Sandler et al., 1975; Bonham Carter et al., 1978; Agren, 1983; Harrison et al., 1983; Harrison et al., 1984). Tyrami ne challenge tests in which p-TA was ingested by normal, migraine (Smith et al., 1971; Youdim et al., 1971) and depressed subjects (Sandler et al., 1975; Bonham Carter et al., 1978; Harrison et al., 1983; Harrison et al., 1984) have shown highly significant reductions in the excretion of conjugated tyramine in the migraine and depressed patients. Consistent with these findings, the activity of platelet phenolsulfotransferase (PST), the conjugating enzyme for p-TA, has been reported to be significantly lower in migraine (Littlewood et al., 1982; Glover et al., 1983). |
