التفاصيل البيبلوغرافية
| العنوان: |
Integrating systems analysis and control for implementing process analytical technology in bioprocess development |
| المؤلفون: |
Viki R. Chopda, James Gomes, Anurag S. Rathore |
| المصدر: |
Journal of Chemical Technology & Biotechnology. 90:583-589 |
| بيانات النشر: |
Wiley, 2014. |
| سنة النشر: |
2014 |
| مصطلحات موضوعية: |
Engineering, Renewable Energy, Sustainability and the Environment, Process (engineering), business.industry, General Chemical Engineering, Process analytical technology, media_common.quotation_subject, Organic Chemistry, Pollution, Unit operation, Industrial engineering, Inorganic Chemistry, Fuel Technology, Systems analysis, Risk analysis (engineering), Process integration, Process control, Quality (business), Bioprocess, business, Waste Management and Disposal, Biotechnology, media_common |
| الوصف: |
This paper provides a perspective on the increasingly critical role that systems analysis and process control play in bioprocess development today. This is of particular importance to the manufacturers of biotech therapeutics since the product quality is critical and depends on the process and its control. Because a large number of process variables and raw materials can influence the overall outcome of a bioprocess, the correct determination of the process trajectory is often an intensive exercise. A follow-up involving design of a suitable process control strategy for implementation of process conditions would be logical. However, such an exercise can no longer consider each unit operation one at a time but rather requires holistic inclusion of all upstream and downstream unit operations for successfully meeting the global standards laid down by various regulatory agencies by exploring the potential of process analytical technology (PAT) to achieve bigger objectives. In this perspective, the focus is on the core issues associated with process integration and how these may influence future process development. © 2014 Society of Chemical Industry |
| تدمد: |
0268-2575 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::8e4ae38583e250d2186ad6332668eafb
https://doi.org/10.1002/jctb.4591 |
| حقوق: |
CLOSED |
| رقم الأكسشن: |
edsair.doi...........8e4ae38583e250d2186ad6332668eafb |
| قاعدة البيانات: |
OpenAIRE |
