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Phorbol 12-myristate 13-acetate prevents apoptosis in erythroleukemia K562 cells induced by some nucleosides

التفاصيل البيبلوغرافية
العنوان: Phorbol 12-myristate 13-acetate prevents apoptosis in erythroleukemia K562 cells induced by some nucleosides
المؤلفون: Malysheva Ie, Nemova Nn, Volkova To
المصدر: Russian Journal of Developmental Biology. 36:14-20
بيانات النشر: Springer Science and Business Media LLC, 2005.
سنة النشر: 2005
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Apoptosis, Cancer cell, Phorbol, Guanosine, Cytidine, DAPI, Biology, Thymidine, Molecular biology, Developmental Biology, K562 cells
الوصف: We studied the ability of phorbol 12-myristate 13-acetat to prevent erythroid differentiation and apoptosis in erythroleukemic K562 cells induced by cytidine, thymidine, and guanosine. The exposure of cancer cells to combinations of phorbol 12-myrsitate 13-acetate (100 nM) nucleosides for two days led to a loss of hemoglobin production (marker of erythroid differentiation) in cells and increased expression of monocyte-macrophage lineage associated surface antigen CD14. The treatment of K562 cells with nucleosides only was accompanied by the activation of caspase-3 and caspase-9, rather than caspase-6, increased fluorescence of ethidium bromide and DAPI upon binding to DNA, and apoptosis. Intracellular activation of caspase-6, inhibition of caspase-9, a markedly decreased activity of caspase-3 and of fluorescence of DNA-binding dyes, and inhibition of apoptosis were observed when the cells were treated with phorbol 12-myeristet 13-acetate combined with nucleosides.
تدمد: 1608-3326
1062-3604
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8eb8faf5bb55ec4a4b893d7ed3d54776
https://doi.org/10.1007/s11174-005-0003-0
حقوق: CLOSED
رقم الأكسشن: edsair.doi...........8eb8faf5bb55ec4a4b893d7ed3d54776
قاعدة البيانات: OpenAIRE
الوصف
تدمد:16083326
10623604