Cytoprotective and antisecretory properties of methanolic extract of Distemonanthus benthamianus (Caesalpiniaceae) stem bark on acute gastric ulcer in rats
| العنوان: | Cytoprotective and antisecretory properties of methanolic extract of Distemonanthus benthamianus (Caesalpiniaceae) stem bark on acute gastric ulcer in rats |
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| المؤلفون: | Gonzal Eric Tsafack, Emakoua J, Vanessa Matah Marthe, Flore Stephanie Djuichou Nguemnang, Herve Tchoumbou Tadjoua, Albert Donatien Atsamo, Flore Carine Adjouzem, Marius Mbiantcha, William Yousseu Nana, Gilbert Ateufack |
| المصدر: | Journal of Complementary and Integrative Medicine. 18:37-49 |
| بيانات النشر: | Walter de Gruyter GmbH, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Ethanol, digestive, oral, and skin physiology, Histaminergic, Pharmacology, Ulcer index, 030226 pharmacology & pharmacy, Mucus, Cytoprotection, digestive system diseases, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Complementary and alternative medicine, chemistry, 030220 oncology & carcinogenesis, Cholinergic, Ligation |
| الوصف: | Objectives In African traditional medicine, Distemonanthus benthamianus (Caesalpiniaceae) is used to treat many diseases including gastric ulcers. We evaluated in this study, the cytoprotective and antisecretory properties of the methanolic extract of the stem bark of this plant using different technics of gastric lesion induction. Methods Cytoprotective and antisecretory activity of the methanolic extract of D. benthamianus stem bark was evolved through six methods of gastric lesion induction in experimental Wistar male rats (150–200 g): (1) gastric lesions induced by HCl/ethanol, (2) gastric lesions induced by Indomethacin- HCl/ethanol, (3) gastric lesion induced by Indomethacin, (4) gastric lesions induced by Pylorus ligation, (5) gastric lesions induced by histamine-Pylorus ligation, (6) gastric lesions induced by carbachol-Pylorus ligation. Mucus and gastric mucosal ulceration were evaluated. pH, gastric volume, and acidity were quantified in all pylorus ligation induction technics. Nitric oxide (NO) level was determined in indomethacin induced gastric ulcers. Results At different doses (125, 250 and 500 mg/kg), extract reduced significantly the ulcer index. In all models used, that is 100.00% with HCl/ethanol; 100.00% with HCl/ethanol/indomethacin; 95.70% with Indomethacin; 74.79% with pylorus ligation, 95.94% histamine-Pylorus ligation, 99.54% carbachol-Pylorus ligation at the highest dose of 500 mg/kg. The lesion formation reduces in all the methods used followed by a significant increase of mucus production. The pylorus ligation technic revealed that the extract has an antisecretory activity. Conclusions The methanolic extract of D. benthamianus stem bark has both cytoprotective and antisecretory effects. This extract exerts its antisecretory effect trough cholinergic and histaminergic pathways. |
| تدمد: | 1553-3840 2194-6329 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::8ec01055063d4db25027fe87bc470889 https://doi.org/10.1515/jcim-2019-0216 |
| رقم الأكسشن: | edsair.doi...........8ec01055063d4db25027fe87bc470889 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15533840 21946329 |
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