Microenvironment-Driven Cascaded Responsive Hybrid Carbon Dots as a Multifunctional Theranostic Nanoplatform for Imaging-Traceable Gene Precise Delivery
| العنوان: | Microenvironment-Driven Cascaded Responsive Hybrid Carbon Dots as a Multifunctional Theranostic Nanoplatform for Imaging-Traceable Gene Precise Delivery |
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| المؤلفون: | Zonghua Liu, Yongcheng Xiao, Cheng-Guang Wu, Haijie Zhao, Wei Xue, Yi Zhang, Guoheng Tang, Junkun Duan |
| المصدر: | Chemistry of Materials. 30:3438-3453 |
| بيانات النشر: | American Chemical Society (ACS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Carbon dot, Polyethylenimine, Chemistry, General Chemical Engineering, Nanotechnology, 02 engineering and technology, General Chemistry, Gene delivery, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Nanomaterials, chemistry.chemical_compound, Materials Chemistry, 0210 nano-technology |
| الوصف: | Imaging-guided stimuli-responsive delivery systems based on nanomaterials for cancer theranostics have been recognized as promising alternatives to traditional therapies in clinic. How to integrate multiple response-mediated nanoproperty (i.e., charge, size, or stability) transitions into a cascaded manner to overcome multistage biological barriers which usually demand different and even opposing nanoproperties in each stage is still a challenge. Herein, a multistage and cascaded responsive theranostic nanoplatform for imaging-traceable TRAIL gene precise delivery was prepared by a cleavable PEGylated shell and a fluorescent carbon dot (CD)-based core. The CDs as the core were prefunctionalized with polyethylenimine end-capped disulfide-bond-bearing hyperbranched poly(amido amine) (HPAP), endowing the CDs with enhanced fluorescent quantum yield (27%), intracellular degradability, and efficient gene delivery capability. The shell was fabricated by dimethylmaleic acid modification of mPEG-PEI600 copolymer a... |
| تدمد: | 1520-5002 0897-4756 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::8f6e31ea93aa7bc9490c7dce3a3e3cd7 https://doi.org/10.1021/acs.chemmater.8b01011 |
| رقم الأكسشن: | edsair.doi...........8f6e31ea93aa7bc9490c7dce3a3e3cd7 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205002 08974756 |
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