Lung transplantation from initially rejected donors after ex vivo lung reconditioning: the French experience†
| العنوان: | Lung transplantation from initially rejected donors after ex vivo lung reconditioning: the French experience† |
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| المؤلفون: | Edouard Sage, Sacha Mussot, Grégoire Trebbia, Philippe Puyo, Marc Stern, Philippe Dartevelle, Alain Chapelier, Marc Fischler, P. Bonnette, D. Mitilian, P. Puyo, N. Salley, E. Sage, A. Chapelier, S. De Miranda, D. Grenet, A. Hamid, C. Picard, A. Roux, M. Stern, J. Bresson, V. Dumans-Nizard, J.L. Dumoulin, S. Ghiglione, S. Jacqmin, M. Le Guen, L. Ley, N. Liu, J.-Y. Marandon, M. Michel-Cherqui, O. Pruszkowski, B. Rives, B. Szekely, B. Vandenbunder, N. Verroust, M. Fischler, J. Devaquet, F. Parquin, A.-G. Si Larbi, G. Trebbia, C. Cerf |
| المصدر: | European Journal of Cardio-Thoracic Surgery. 46:794-799 |
| بيانات النشر: | Oxford University Press (OUP), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Lung, business.industry, Mortality rate, medicine.medical_treatment, Incidence (epidemiology), Primary Graft Dysfunction, General Medicine, Intensive care unit, law.invention, Transplantation, medicine.anatomical_structure, law, Anesthesia, medicine, Lung transplantation, Surgery, Cardiology and Cardiovascular Medicine, business, Ex vivo |
| الوصف: | OBJECTIVES Only 15% of brain death donors are considered suitable for lung transplantation (LTx). The normothermic ex vivo lung perfusion technique is used to potentially increase the availability of high-risk lung donors. We report our experience of LTx with initially rejected donors after ex vivo lung reconditioning (EVLR). METHODS From April 2011 to May 2013, we performed EVLR for 32 pairs of donor lungs deemed unsuitable for transplantation and rejected by the 11 French lung transplant teams. After EVLR, lungs with acceptable function were transplanted. During the same period, 81 double-lung transplantations (DLTx) were used as controls. RESULTS During EVLR, 31 of 32 donor lungs recovered physiological function with a median PO2/FiO2 ratio increasing from 274 (range 162-404) mmHg to 511 (378-668) mmHg at the end of EVLR (P < 0.0001). Thirty-one DLTx were performed. The incidence of primary graft dysfunction 72 h after LTx was 9.5% in the EVLR group and 8.5% in the control group (P = 1). The median time of extubation, intensive care unit and hospital lengths of stay were 1, 9 and 37 days in the EVLR group and 1 (P = 0.17), 6 (P = 0.06) and 28 days (P = 0.09) in the control group, respectively. Thirty-day mortality rates were 3.3% (n = 1) in the EVLR group and 3.7% (n = 3) in the control group (P = 0.69). One-year survival rates were 93% in the EVLR group and 91% in the control group. CONCLUSIONS EVLR is a reliable and repeatable technique that offers a significant increase of available donors. The results of LTx with EVLR lungs are similar to those obtained with conventional donors. |
| تدمد: | 1873-734X 1010-7940 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::923fbb1d5901103b0dd8e6fc48ed78f2 https://doi.org/10.1093/ejcts/ezu245 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........923fbb1d5901103b0dd8e6fc48ed78f2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1873734X 10107940 |
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