Peutz-Jeghers syndrome. A clinicopathologic study of a large family with a 27-year follow-up
| العنوان: | Peutz-Jeghers syndrome. A clinicopathologic study of a large family with a 27-year follow-up |
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| المؤلفون: | John T. Prior, Daniel Burdick |
| المصدر: | Cancer. 50:2139-2146 |
| بيانات النشر: | Wiley, 1982. |
| سنة النشر: | 1982 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Pathology, business.industry, Peutz–Jeghers syndrome, medicine.disease, Malignancy, Fibroadenoma, Gastroenterology, digestive system diseases, Jejunum, medicine.anatomical_structure, Oncology, Internal medicine, Carcinoma, Medicine, Adenocarcinoma, Mesenteric lymph nodes, skin and connective tissue diseases, business, Intestinal Cancer |
| الوصف: | A family group of ten patients with the Peutz-Jeghers syndrome has been followed for a 27-year period. Eight members of the family had one or more manifestations of the syndrome. One member of the family died following a bypass procedure of a nonresectable carcinoma of the jejunum. Postmortem examination revealed this to be an adenocarcinoma of the jejunum arising in a Peutz-Jeghers polyp and metastases were present in the mesenteric lymph nodes. Two members of the family developed breast carcinomas, one arising in a fibroadenoma; both patients died, one of metastatic breast carcinoma, the other of a second primary malignancy (adenocarcinoma of the jejunum arising in a Peutz-Jeghers polyp). Three family members had benign ovarian tumors, one patient had a benign breast tumor and another patient had a benign colloid thyroid nodule. While the authors of this report believe that they have added a documented case of an adenocarcinoma of the jejunum arising in a Peutz-Jeghers polyp to the literature, the exact risk of intestinal cancer in the Peutz-Jeghers syndrome is unknown, but probably very small. Gastrointestinal surgery should continue to be performed in symptomatic patients and all patients should be followed closely at regular intervals. |
| تدمد: | 1097-0142 0008-543X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::927de4212d1a01ccc90b4c96830a0767 https://doi.org/10.1002/1097-0142(19821115)50:10<2139::aid-cncr2820501028>3.0.co;2-k |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........927de4212d1a01ccc90b4c96830a0767 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
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