The associations of gut microbiota and fecal short-chain fatty acids with bone mass were largely mediated by weight status: a cross-sectional study
| العنوان: | The associations of gut microbiota and fecal short-chain fatty acids with bone mass were largely mediated by weight status: a cross-sectional study |
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| المؤلفون: | Qinzhi Wei, Yuanhuan Wei, Zhuang Cui, Jialiang Pan, William Kwame Amakye, Dafeng Xu, Fengyan Chen, Zheqing Zhang, Jue Wang |
| المصدر: | European Journal of Nutrition. 60:4505-4517 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Bone mineral, medicine.medical_specialty, 030109 nutrition & dietetics, Nutrition and Dietetics, biology, Bone density, Cross-sectional study, Medicine (miscellaneous), 030209 endocrinology & metabolism, Standard score, Gut flora, biology.organism_classification, Body weight, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, medicine, Feces, Bone mass |
| الوصف: | We aimed to investigate whether the gut microbiota and fecal short-chain fatty acids (SCFAs) are associated with bone mass in healthy children aged 6–9 years. In this study, 236 healthy children including 145 boys and 91 girls were enrolled. 16S rRNA gene sequencing was used to characterize the composition of their gut microbiota. Total and 10 subtypes of SCFAs in the fecal samples were determined by high-performance liquid chromatography. Dual X-ray absorptiometry was used to measure the bone mineral density (BMD) and bone mineral content (BMC) for total body (TB) and total body less head (TBLH). Z score of TBLH BMD was calculated based on the recommended reference. Four gut microbiota principal components (PCs) were identified by the compositional principal component analysis at the genus level. After adjustment of covariates and controlling for the false discovery rate, multiple linear regression analysis showed that PC3 score (positive loadings on genera Lachnoclostridium and Blautia) was significantly negatively associated with TBLH BMD/BMC/Z score, TB BMC and pelvic BMD (β: − 0.207 to − 0.108, p: 0.002–0.048), whereas fecal total and several subtypes of SCFAs were correlated positively with TBLH BMD/Z score and pelvic BMD (β: 0.118–0.174, p: 0.038–0.048). However, these associations disappeared after additional adjustment for body weight. Mediation analysis suggested that body weight significantly mediated 60.4% and 78.0% of the estimated association of PC3 score and SCFAs with TBLH BMD Z score, respectively. The associations of gut microbiota composition and fecal SCFA concentrations with bone mass in children were largely mediated by body weight. |
| تدمد: | 1436-6215 1436-6207 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::932ab2adfb2967eaee224b42ddb0cd5a https://doi.org/10.1007/s00394-021-02597-x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........932ab2adfb2967eaee224b42ddb0cd5a |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14366215 14366207 |
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