Crosslinked chitosan-based particles obtained by water-in-oil emulsion technique
| العنوان: | Crosslinked chitosan-based particles obtained by water-in-oil emulsion technique |
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| المؤلفون: | Sofia Milenkova, Maria Marudova, Nikolay Zahariev, Temenuzhka Yovcheva, Bissera Pilicheva |
| المصدر: | Journal of Physics: Conference Series. 2436:012027 |
| بيانات النشر: | IOP Publishing, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | History, Computer Science Applications, Education |
| الوصف: | Particles based on emulsified chitosan in oil phase have been reported in the present study. Sodium Tripolyphosphate (NaTPP) was introduced to them as a crosslinker and its effect on their properties was examined. Laser diffraction technique showed that the obtained structures are micronsized particles with single modal distribution. Optical microscopy has confirmed their size range, together with the fact that their shape is regular and spherical. Swelling studies in simulated saliva conditions (pH = 6.8) has shown a relation between the crosslinking degree of the particles and cycles of swelling and dissolution at different rates. Mucoadhesion test confirmed their potential as delivery systems through a mucosal route and showed dependence of the mucoadhesion properties upon the free amino groups left onto the chitosan chains. |
| تدمد: | 1742-6596 1742-6588 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::957a8a2adfeece9e160598d4cf110f83 https://doi.org/10.1088/1742-6596/2436/1/012027 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........957a8a2adfeece9e160598d4cf110f83 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17426596 17426588 |
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