Baseline stool toxin concentration is associated with risk of recurrence in children with Clostridioides difficile infection
| العنوان: | Baseline stool toxin concentration is associated with risk of recurrence in children with Clostridioides difficile infection |
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| المؤلفون: | Thomas J. Sandora, Larry K. Kociolek, David N. Williams, Kaitlyn Daugherty, Christine Geer, Christine Cuddemi, Xinhua Chen, Hua Xu, Timothy J. Savage, Alice Banz, Kevin W. Garey, Anne J. Gonzales-Luna, Ciarán P. Kelly, Nira R. Pollock |
| المصدر: | Infection Control & Hospital Epidemiology. :1-7 |
| بيانات النشر: | Cambridge University Press (CUP), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Microbiology (medical), Infectious Diseases, Epidemiology |
| الوصف: | Background: In adults with Clostridioides difficile infection (CDI), higher stool concentrations of toxins A and B are associated with severe baseline disease, CDI-attributable severe outcomes, and recurrence. We evaluated whether toxin concentration predicts these presentations in children with CDI. Methods: We conducted a prospective cohort study of inpatients aged 2–17 years with CDI who received treatment. Patients were followed for 40 days after diagnosis for severe outcomes (intensive care unit admission, colectomy, or death, categorized as CDI primarily attributable, CDI contributed, or CDI not contributing) and recurrence. Baseline stool toxin A and B concentrations were measured using ultrasensitive single-molecule array assay, and 12 plasma cytokines were measured when blood was available. Results: We enrolled 187 pediatric patients (median age, 9.6 years). Patients with severe baseline disease by IDSA-SHEA criteria (n = 34) had nonsignificantly higher median stool toxin A+B concentration than those without severe disease (n = 122; 3,217.2 vs 473.3 pg/mL; P = .08). Median toxin A+B concentration was nonsignificantly higher in children with a primarily attributed severe outcome (n = 4) versus no severe outcome (n = 148; 19,472.6 vs 429.1 pg/mL; P = .301). Recurrence occurred in 17 (9.4%) of 180 patients. Baseline toxin A+B concentration was significantly higher in patients with versus without recurrence: 4,398.8 versus 280.8 pg/mL (P = .024). Plasma granulocyte colony-stimulating factor concentration was significantly higher in CDI patients versus non-CDI diarrhea controls: 165.5 versus 28.5 pg/mL (P < .001). Conclusions: Higher baseline stool toxin concentrations are present in children with CDI recurrence. Toxin quantification should be included in CDI treatment trials to evaluate its use in severity assessment and outcome prediction. |
| تدمد: | 1559-6834 0899-823X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::958b2ebc1b70da5bc42fa9b2d5b7554f https://doi.org/10.1017/ice.2022.310 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........958b2ebc1b70da5bc42fa9b2d5b7554f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15596834 0899823X |
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