Application of the Polymerase Chain Reaction to the Diagnosis and Management of Neonatal Herpes Simplex Virus Disease
| العنوان: | Application of the Polymerase Chain Reaction to the Diagnosis and Management of Neonatal Herpes Simplex Virus Disease |
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| المؤلفون: | Charles G. Prober, Ann M. Arvin, Dwight A. Powell, Stuart E. Starr, Lawrence Corey, Richard J. Whitley, David W. Kimberlin, Richard F. Jacobs, Sandra K. Burchett, Fred D. Lakeman |
| المصدر: | Journal of Infectious Diseases. 174:1162-1167 |
| بيانات النشر: | Oxford University Press (OUP), 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | medicine.medical_specialty, biology, business.industry, medicine.disease_cause, medicine.disease, biology.organism_classification, Virus, Herpesviridae, law.invention, Infectious Diseases, Herpes simplex virus, law, Alphaherpesvirinae, Internal medicine, Immunology, medicine, Immunology and Allergy, Viral disease, business, Vidarabine, Polymerase chain reaction, Encephalitis, medicine.drug |
| الوصف: | Cerebrospinal fluid (CSF) specimens from 77 neonates with herpes simplex virus (HSV) disease were evaluated retrospectively by polymerase chain reaction (PCR). Samples were collected from 202 infants enrolled in a National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group trial that compared vidarabine with acyclovir for the treatment of neonatal HSV infection. HSV DNA was detected in the CSF of 26 (76%) of 34 infants with CNS disease, in 13 (93%) of 14 infants with disseminated infection, and in 7 (24%) of 29 with skin, eye, or mouth (SEM) involvement. One of the 7 PCR-positive SEM patients subsequently developed severe neurologic impairment. Eighteen (95%) of 19 infants with positive CSF PCR results after the completion of 10 days of antiviral therapy experienced significant morbidity or mortality. Application of PCR to neonatal HSV disease may provide additional information on which clinical decisions may be based, although its diagnostic utility outside the research setting is unproven. |
| تدمد: | 1537-6613 0022-1899 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::9774adc18b17ff8261876ddad57cf333 https://doi.org/10.1093/infdis/174.6.1162 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........9774adc18b17ff8261876ddad57cf333 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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