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Balancing Effect of Biejiajian Oral Liquid (鳖甲煎口服液) on ACE-Ang II-AT1R Axis and ACE2-Ang-(1–7)-Mas Axis in Rats with CCl4-Induced Hepatic Fibrosis

التفاصيل البيبلوغرافية
العنوان: Balancing Effect of Biejiajian Oral Liquid (鳖甲煎口服液) on ACE-Ang II-AT1R Axis and ACE2-Ang-(1–7)-Mas Axis in Rats with CCl4-Induced Hepatic Fibrosis
المؤلفون: Li Yao, Yan Peng, Xia-wei Bu, Jia Yao, Xiao-ya Li
المصدر: Chinese Journal of Integrative Medicine. 24:853-859
بيانات النشر: Springer Science and Business Media LLC, 2018.
سنة النشر: 2018
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, business.industry, Vitamin E, medicine.medical_treatment, CCL4, General Medicine, Angiotensin II, 03 medical and health sciences, Subcutaneous injection, chemistry.chemical_compound, 030104 developmental biology, Endocrinology, Complementary and alternative medicine, chemistry, Internal medicine, Renin–angiotensin system, Carbon tetrachloride, medicine, Pharmacology (medical), Enalapril, Hepatic fibrosis, business, hormones, hormone substitutes, and hormone antagonists, medicine.drug
الوصف: To explore the effect of Biejiajian Oral Liquid (鳖甲煎口服液, BOL) on CCl4-induced hepatic fibrosis in rats by detecting the changes in the levels of angiotensin II (Ang II), angiotensin-(1–7) [Ang-(1–7)], angiotensin-converting enzyme (ACE), ACE2, angiotensin II type 1 receptor (AT1R), Mas, etc. A total of 180 Wistar rats were randomly divided into two groups by random digital table method: prevention experiment and treatment experiment. Each group was further subdivided into the following 6 subgroups: normal control group, model group, vitamin E [100 mg/(kg·d), VE] group, enalapril [10 mg/(kg·g), Ena] group, high-dosage [20 g/(kg·d)] BOL group, and low-dosage [10 g/(kg·d)] BOL group. The hepatic fibrosis rat model was established by subcutaneous injection of CCl4 for 6 weeks. Prevention experiment and treatment experiment were administered with specific drugs at different times. At the end of treatment experiment, the pathological changes of liver were observed after hematoxylin-eosin staining. The expressions of ingredients in renin-angiotensin-aldosterone system (RAAS) such as AngII, Ang-(1–7), ACE, ACE2, AT1R, Mas, renin, CYP11B2 and angen in liver were detected by enzyme linked immunosorbent assay, immunohistochemistry method or reverse transcription-polymerase chain reaction, respectively. The levels of AngII and Ang-(1–7) at the 6th week increased by 496.10% and 73.64%, respectively, compared with those at the 2nd week in the model group (P
تدمد: 1993-0402
1672-0415
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::983af733b39719900e50ee78b84b4c11
https://doi.org/10.1007/s11655-017-2909-7
حقوق: CLOSED
رقم الأكسشن: edsair.doi...........983af733b39719900e50ee78b84b4c11
قاعدة البيانات: OpenAIRE
الوصف
تدمد:19930402
16720415