Catalase-like quantum dots of l-lysine polymerization as free radical scavengers for hypoxic brain injury

التفاصيل البيبلوغرافية
العنوان: Catalase-like quantum dots of l-lysine polymerization as free radical scavengers for hypoxic brain injury
المؤلفون: Yuan-Ming Sun, Hua He, Haile Liu, Junying Wang, Lei Zhou, Qifeng Li, Qinjuan Ren, Si Sun, Yalong Gao, Jun Shen, Xiaodong Zhang, Wei Long, Xiaoyu Mu, Jiahui Pei, Jianning Zhang, Lufei Ouyang, Ke Chen
المصدر: Materials Today Communications. 27:102286
بيانات النشر: Elsevier BV, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Materials science, Traumatic brain injury, Radical, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Oxygen, chemistry.chemical_compound, In vivo, Materials Chemistry, medicine, General Materials Science, Hydrogen peroxide, biology, 021001 nanoscience & nanotechnology, medicine.disease, 0104 chemical sciences, chemistry, Mechanics of Materials, Catalase, Quantum dot, biology.protein, Biophysics, 0210 nano-technology, Oxidative stress
الوصف: Hypoxemia as one of the most common symptoms of traumatic brain injury (TBI) can significantly exacerbate the development of secondary damage, which further contributes to generating large numbers of neurotoxic factors such as reactive oxygen and nitrogen species (RONS), pro-inflammatory cytokine and chemokine. Here, we developed a kind of quantum dots as catalase-mimic and multiple free radical scavengers by means of the microwave heating polymerization of l -lysine. Hydrogen peroxide as overproduced radicals can be decomposed to supply oxygen, contributing to improving the hypoxic condition in brain. Simultaneously, other traditional RONS such as O2 −, OH, NO and ONOO− can be eliminated by the quantum dots. The total ROS level is back to normal after the quantum dots treatment, promoting the H2O2/LPS-stimulated cell survival in vitro. Oxidative stress induced by hypoxic brain injury is restored by the quantum dots intravenous injection, leading to the protection of neural cells in vivo. Additionally, the quantum dots can improve the spatial learning and memory of TBI mice by water maze test. This work provides a new perspective for the therapy of hypoxic brain injury.
تدمد: 2352-4928
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9874554cf8ba0109126b2fa2f15558f3
https://doi.org/10.1016/j.mtcomm.2021.102286
حقوق: CLOSED
رقم الأكسشن: edsair.doi...........9874554cf8ba0109126b2fa2f15558f3
قاعدة البيانات: OpenAIRE