التفاصيل البيبلوغرافية
| العنوان: |
Mitochondrial Dysfunction and Ca2+ Overload in Injured Sertoli Cells Exposed to Bisphenol A |
| المؤلفون: |
Chao Quan, Suqin Qi, Kedi Yang, Wenjuan Fu, Tingting Yu, Aixia Yang, Peng Duan, Chengmin Wang, Changjiang Liu |
| المصدر: |
Environmental Toxicology. 32:823-831 |
| بيانات النشر: |
Wiley, 2016. |
| سنة النشر: |
2016 |
| مصطلحات موضوعية: |
0301 basic medicine, endocrine system, medicine.medical_specialty, Bisphenol A, Programmed cell death, Health, Toxicology and Mutagenesis, 010501 environmental sciences, Management, Monitoring, Policy and Law, Biology, Mitochondrion, Toxicology, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Internal medicine, medicine, 0105 earth and related environmental sciences, Calcium metabolism, urogenital system, General Medicine, Sertoli cell, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, Apoptosis, Cytoplasm, Toxicant |
| الوصف: |
Bisphenol-A (BPA) is well known as one of endocrine-disrupting chemicals and testicular toxicant. In this present study, we determined whether BPA caused cell injury through mitochondria impairment and ROS overproduction. The cellular ROS production, mitochondrial ATP synthetase activity and Ca2+ concentration were examined. We have found BPA caused the cellular mitochondria dysfunction and followed by cell death in Sertoli cells. Moreover cytoplasm Ca2+ overload was also involved. Furthermore, pretreatment with N-acetyl-L-cysteine (NAC) could alleviate the damage by causing a remarkable decrease in ROS production and mitochondrial dysfunction. Collectively, our results showed that BPA exposure induced Sertoli cell apoptosis because of excessive ROS generation and mitochondrial dysfunction. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 823-831, 2017. |
| تدمد: |
1520-4081 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::99360955d438e981abf9fb8d3e3c99aa
https://doi.org/10.1002/tox.22282 |
| حقوق: |
CLOSED |
| رقم الأكسشن: |
edsair.doi...........99360955d438e981abf9fb8d3e3c99aa |
| قاعدة البيانات: |
OpenAIRE |
