Pharmacokinetics of Benzylpenicillin (Penicillin G) during Prolonged Intermittent Renal Replacement Therapy
| العنوان: | Pharmacokinetics of Benzylpenicillin (Penicillin G) during Prolonged Intermittent Renal Replacement Therapy |
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| المؤلفون: | Matthew Rawlins, Christopher T. Allen, Tim Chang, Emma Fox, Edward Litton, Vesa Cheng, Jason A. Roberts, Michael M. Page, John Dyer, Kirsten Hoad |
| المصدر: | Chemotherapy. 64:17-21 |
| بيانات النشر: | S. Karger AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.drug_class, medicine.medical_treatment, 030106 microbiology, Antibiotics, Pharmacology, Benzylpenicillin, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Drug Discovery, polycyclic compounds, medicine, Pharmacology (medical), Renal replacement therapy, Dosing, business.industry, General Medicine, medicine.disease, Penicillin, Infectious Diseases, Oncology, 030220 oncology & carcinogenesis, Infective endocarditis, Pharmacodynamics, business, medicine.drug |
| الوصف: | Prolonged intermittent renal replacement therapy (PIRRT) is an increasingly adopted method of renal replacement in critically ill patients. Like continuous renal replacement therapy, PIRRT can alter the pharmacokinetics (PK) of many drugs. In this setting, dosing data for antibiotics like benzylpenicillin are lacking. In order to enable clinicians to prescribe benzylpenicillin safely and effectively, knowledge of the effects of PIRRT on the plasma PK of benzylpenicillin is required. Herein, we describe the PK of benzylpenicillin in 2 critically ill patients on PIRRT for the treatment of penicillin-susceptible Staphylococcus aureus bacteremia complicated by infective endocarditis. Blood samples were taken for each patient taken over dosing periods during PIRRT and off PIRRT. Two-compartment PK models described significant differences in the mean clearance of benzylpenicillin with and without PIRRT (6.61 vs. 3.04 L/h respectively). We would suggest a benzylpenicillin dose of 1,800 mg (3 million units) every 6-h during PIRRT therapy as sufficient to attain PK/pharmacodynamic target. |
| تدمد: | 1421-9794 0009-3157 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::99edcaa51c19e4fc3c25b55181db4b9f https://doi.org/10.1159/000499375 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........99edcaa51c19e4fc3c25b55181db4b9f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219794 00093157 |
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