ChemInform Abstract: First Asymmetric Synthesis of a 6-Alkoxy-5,6-dihydro-1,3-oxazine: A Promising Enantioselective Route to β-Amido Aldehydes
| العنوان: | ChemInform Abstract: First Asymmetric Synthesis of a 6-Alkoxy-5,6-dihydro-1,3-oxazine: A Promising Enantioselective Route to β-Amido Aldehydes |
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| المؤلفون: | Loic Toupet, Patricia Gizecki, Gilles Dujardin, Robert Dhal |
| المصدر: | ChemInform. 31 |
| بيانات النشر: | Wiley, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | chemistry.chemical_compound, Hydrolysis, Enantiopure drug, chemistry, Imine, Alkoxy group, Enantioselective synthesis, Organic chemistry, General Medicine |
| الوصف: | The 1,3-oxazine route to enantiopure β-amido aldehydes was investigated. Heterocycloaddition of the N-acyl imine 1 with (R)-O-vinylpantolactone provided the stable dihydroxazine 4c. High diastereocontrols were observed when using Yb(fod)3-catalyzed or SnCl4-mediated conditions, thus leading after quantitative hydrolysis to (R)-N-benzoyl-3-phenylpropanal with >98% ee. |
| تدمد: | 1522-2667 0931-7597 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::9afef4b202d0c98baa6a81d22d934d62 https://doi.org/10.1002/chin.200025163 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........9afef4b202d0c98baa6a81d22d934d62 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15222667 09317597 |
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