Incidence, clinical correlates and associated outcomes of dementia in heart failure: a population-based cohort study
| العنوان: | Incidence, clinical correlates and associated outcomes of dementia in heart failure: a population-based cohort study |
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| المؤلفون: | Q W Ren, T H K Teng, T Wang, Y K Tse, P F Wong, H L Li, S Y Yu, M Z Wu, X L Li, H F Tse, C S P Lam, K H Yiu |
| المصدر: | European Heart Journal. 43 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine |
| الوصف: | Funding Acknowledgements Type of funding sources: None. Background Dementia, in the setting of heart failure (HF), portends poorer outcomes and poses great challenges in its clinical management. Purpose We investigated the incidence, types, clinical correlates, and the prognostic impact of dementia in a population-based cohort of patients with HF. Further, we examined the interactions of age and sex, and education status with dementia incidence. Methods The previously validated Hong Kong Clinical Data Analysis Reporting System (CDARS), a territory-wide database was interrogated to identify patients with HF (N= 202,121) from 1995 to 2018. Associations of clinical correlates with incident dementia and its risk with all-cause mortality were assessed using competing risk/multivariable Cox regression models where appropriate. Results Among a total cohort aged ≥18 years with HF (mean age: 75.3 ± 13.0 years, 51.3% women), new-onset dementia occurred in 22,145 (11.0%) over a median follow-up of 5.5 years. Alzheimer’s disease occurred in 27.0%; vascular dementia (18.1%) and unspecified dementia (in 55.1%). Age-standardized rate of dementia incidence in women was 1297 (95%CI, 1276-1318) (vs. 744, 95%CI, 723-765) per 10000 population in men. Other independent predictors of dementia include: Increasing age (HR 1.08), Female sex (HR 1.19), Nil/< primary (vs tertiary) education (HR 1.29), Parkinson’s disease (HR 1.73), head injury (HR 1.37), peripheral vascular disease (HR 1.31), stroke (HR 1.29), depression (HR 1.18), alcohol intake (HR1.17), anaemia (HR 1.14), hypertension (HR 1.08), among other common comorbidities in HF (Figure 1A). Notably, a significant interaction (p Conclusions Female sex, lower socioeconomic status, increasing age and common comorbidities were associated with higher hazards of incident dementia. Abstract Figure 1A and Figure 1B |
| تدمد: | 1522-9645 0195-668X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::9d3b85bafd0981176ad8719a8c83229c https://doi.org/10.1093/eurheartj/ehab849.046 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........9d3b85bafd0981176ad8719a8c83229c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229645 0195668X |
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