Late potentials assessment - an useful tool for Brugada Syndrome risk stratification
| العنوان: | Late potentials assessment - an useful tool for Brugada Syndrome risk stratification |
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| المؤلفون: | J Brito, P Silverio Antonio, A Nunes Ferreira, G Lima Da Silva, I Ricardo, I Neves, N Cortez-Dias, F J Pinto, J Sousa |
| المصدر: | Europace. 25 |
| بيانات النشر: | Oxford University Press (OUP), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Physiology (medical), Cardiology and Cardiovascular Medicine |
| الوصف: | Funding Acknowledgements Type of funding sources: None. Introduction Brugada syndrome (BrS) is a channelopathy confining an increased risk of sudden cardiac death (SCD). Asymptomatic patients (pts) management remains challenging enhancing the necessity for additionally stratification tools. Purpose To evaluate the role of the non-invasive assessment of late potentials (LP) based on SA-ECG as stratification tools in a BrS cohort. Methods Prospective, observational single-center study of pts with BrS with the following criteria (1) Type 1 Brugada ECG pattern, either spontaneous or drug induced; (2) SA-ECG performed before anti-arrhythmic treatment; (3) minimum follow up duration of 12 months. LPs were evaluated by SA-ECG with determination of the total filtered QRS duration (fQRS); root mean square voltage of the 40ms terminal portion of the QRS (RMS40) and duration of the low amplitude electric potential component of the terminal portion of the QRS (LAS40) in conventional and modified right precordial leads. Malignant arrhythmic events (MAEs) were defined as a composite event of SCD or appropriate ICD shocks. Association of relevant risk factors and MAE was conducted with Univariate Cox regression analysis, as well as SA-ECG evaluated as a continuous and categorical divided on standard cut-offs (fQRS >114ms, RMS4038ms). A risk score for predicting MAE was computed incorporating the significant LPs variables. Results A total of 106 pts fulfilled the inclusion criteria (mean age: 48 ± 12 years, 67.9% male), 52 (49.1%) with type 1 spontaneous pattern. The majority were asymptomatic at baseline (81.1%) while 13 presented with syncope and 3 with polymorphic VT/cardiac arrest. A total of 10 (7.1%) pts MAEs were documented during a mean 4.7 years - 4 with SCD and 6 with appropriate ICD shocks. Clinical presentation with a polymorphic VT/cardiac arrest (p Conclusion LPs based on noninvasive assessment SAECG represent an useful prognostic stratification tool in BrS. A LP score based on standard cut-offs identified a subset of pts at a higher risk of events and who may deserve individualized preventive strategies. |
| تدمد: | 1532-2092 1099-5129 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::9d9e6140309c6fec05397296cc4814b6 https://doi.org/10.1093/europace/euad122.624 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........9d9e6140309c6fec05397296cc4814b6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15322092 10995129 |
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