Aims: To ensure effectiveness of COVID 19 vaccine in controlling the pandemic, high vaccination coverage rates are necessary to achieve herd immunity which will help reduce the transmission of the virus and ensure reduction in the risk of transmission of infection. The study assessed COVID-19 vaccine uptake and its determinants among the adult population in Somali region of Ethiopia. Study Design: This was a cross-sectional analytical study Place and Duration of Study: Somali Region of Ethiopia in October 2021 Methodology: A structured interviewer-administered questionnaire adapted from the World Health Organization (WHO) Strategic Advisory Group of Experts on Immunisation vaccine hesitancy survey question, administered to 433 adult population in eight selected sites. Bivariate analysis and multiple logistic regression were used to test association between vaccine uptake and some selected determinants. The level of significance was set at a p-value
