Methanol fraction of Ficus mucoso (welw) prevents iron-induced oxidative damage and alters mitochondrial dysfunction in Drosophila melanogaster
| العنوان: | Methanol fraction of Ficus mucoso (welw) prevents iron-induced oxidative damage and alters mitochondrial dysfunction in Drosophila melanogaster |
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| المؤلفون: | Hammed O. Faleke, Olufunso O. Olorunsogo, Olubukola T. Oyebode, Amos O. Abolaji |
| المصدر: | Drug and Chemical Toxicology. 45:2644-2652 |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pharmacology, Chemical Health and Safety, Antioxidant, biology, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Public Health, Environmental and Occupational Health, General Medicine, Glutathione, Mitochondrion, Toxicology, Malondialdehyde, medicine.disease_cause, chemistry.chemical_compound, chemistry, Mitochondrial permeability transition pore, Catalase, Toxicity, medicine, biology.protein, Oxidative stress |
| الوصف: | The present study investigated the antioxidant and cyto-/mito-protective roles of Methanol Fraction of Ficus mucoso (MFFM) in iron-induced oxidative damage in Drosophila melanogaster. At first, 10-day survival rates were carried out separately on FeSO4 and MFFM, respectively, after which ameliorative effects of MFFM were investigated on FeSO4-induced toxicity for 5 days using biochemical and behavioral markers. Additionally, mitochondria were isolated from treated D. melanogaster to assess mitochondrial Permeability Transition (mPT) pore opening. The results showed that FeSO4 significantly reduced survival rate, total thiol level and activities of catalase and glutathione-S-transferase in D. melanogaster. In addition, treatment with FeSO4 caused increased generation of H2O2, NO (nitrite/nitrates) and acetylcholinesterase (AChE) activity compared with control (p |
| تدمد: | 1525-6014 0148-0545 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::9f6726e38879e1c5b6ac87a6fe58cc6a https://doi.org/10.1080/01480545.2021.1979997 |
| رقم الأكسشن: | edsair.doi...........9f6726e38879e1c5b6ac87a6fe58cc6a |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15256014 01480545 |
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