Sustained vasodilation after cold pressor test is an independent predictor of poor survival in primary AL amyloidosis
| العنوان: | Sustained vasodilation after cold pressor test is an independent predictor of poor survival in primary AL amyloidosis |
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| المؤلفون: | R Patras, G Georgiopoulos, I Petropoulos, F Theodorakakou, D Delialis, L Angelidakis, M Gavriatopoulou, M A Dimopoulou, A Sianis, E Maneta, O Neofytou, E Terpos, M A Dimopoulos, E Kastritis, K Stamatelopoulos |
| المصدر: | European Heart Journal. 43 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine |
| الوصف: | Background Primary AL amyloidosis is a rare yet lethal systemic disorder. Dysfunction of the autonomous nervous system due to disease-related nerve infiltration is a common manifestation of AL amyloidosis. Previously published own work indicated that AL patients present sustained paradoxical vasodilation in response to sympathetic stimulus, as assessed by cold pressor test (CPT). The clinical relevance of this finding is unknown. Purpose We sought to investigate the relationship between CPT-induced vascular response and mortality in AL amyloidosis. Methods We consecutively recruited 97 newly diagnosed patients with AL amyloidosis. CPT of the brachial artery was performed before treatment initiation. All measurements were assessed using high resolution ultrasonography (14.0Mhz multifrequency linear array probe, Vivid 7 Pro; General Electric Healthcare, Milwaukee, Wisconsin, USA). The maximum vasodilation of the brachial artery was measured during the sympathetic stimulus and 3 minutes after withdrawal (sustained response). All-cause mortality was defined as the primary end-point of the study. Results Mean age was 66 years with prevalence of male gender. Sustained vasodilation (but not vasodilation during CPT) was associated with heart failure, NYHA stage, BNP and peripheral vascular involvement (p Conclusions In AL amyloidosis, sustained paradoxical vasodilation in response to sympathetic stimulus was associated with poor survival. The clinical utility of this index of vascular autonomic dysfunction as a potential prognostic and therapeutic biomarker in AL amyloidosis merits further investigation. Funding Acknowledgement Type of funding sources: None. |
| تدمد: | 1522-9645 0195-668X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::a072fc7438934aa72e82fb7994347e9d https://doi.org/10.1093/eurheartj/ehac544.1790 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........a072fc7438934aa72e82fb7994347e9d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229645 0195668X |
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