Exploratory cost-effectiveness analysis of 68Gallium-PSMA PET/MRI-based imaging in patients with biochemical recurrence of prostate cancer
| العنوان: | Exploratory cost-effectiveness analysis of 68Gallium-PSMA PET/MRI-based imaging in patients with biochemical recurrence of prostate cancer |
|---|---|
| المؤلفون: | Elizabeth D. Williams, Louisa G. Gordon, Andre Joshi, Ian Vela, Thomas M. Elliott |
| المصدر: | Clinical & Experimental Metastasis. 37:305-312 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Biochemical recurrence, Cancer Research, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, General Medicine, Cost-effectiveness analysis, urologic and male genital diseases, medicine.disease, 03 medical and health sciences, Prostate cancer, 030104 developmental biology, 0302 clinical medicine, Oncology, Positron emission tomography, Surgical oncology, 030220 oncology & carcinogenesis, Medicine, In patient, Radiology, Stage (cooking), business |
| الوصف: | Men treated for prostate cancer with curative intent face a recurrence rate of up to 53% at 10 years. 68Ga-PSMA imaging is a new technique that can more accurately stage cancer recurrences and facilitate personalised treatment. We evaluated the cost-effectiveness of 68Ga-PSMA PET/MRI for staging men with prostate cancer biochemical recurrence. A cost-effectiveness analysis using a decision-analytic model with Markov chains was constructed. 68Ga-PSMA PET/MRI was compared with usual care in staging of men with suspected prostate cancer recurrence. Men with biochemical recurrence from a study in Brisbane, Australia (n = 30) provided key estimates for the model. The primary outcomes were health system costs and years of life (survival) over 10 years. Deterministic and probabilistic sensitivity analyses were undertaken to address uncertainty in model estimates. On average, a strategy of 68Ga-PSMA was expected to cost AU$56 961(US$39 426) and produce 7.48 life years compared with AU$64 499 (US$44 667) and 7.41 life years in usual care. Therefore, 68Ga-PSMA was potentially cost saving (− AU$7 592 95% UI − $24 846, $7 825) (− US$5 258) and slightly more effective 0.07 life years (95% UI − 0.01, 0.16). The likelihood that 68Ga-PSMA strategy was cost-effective at acceptable thresholds was 87%. The findings were sensitive to the lesion detection rate of the 68Ga-PSMA strategy (52–75%) and the cost of follow up in usual care (AU$1 947 to $2 635). In this exploratory economic evaluation, using 68Ga-PSMA PET/MRI to detect prostate cancer recurrence appears to be cost-effective relative to usual care. |
| تدمد: | 1573-7276 0262-0898 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::a0f4a56481f28bd39c58207e4d701a65 https://doi.org/10.1007/s10585-020-10027-1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........a0f4a56481f28bd39c58207e4d701a65 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15737276 02620898 |
|---|