Synthesis and Anticancer Activity of New Thiophene, Thiazolyl-Thiophene, and Thienopyridine Derivatives
| العنوان: | Synthesis and Anticancer Activity of New Thiophene, Thiazolyl-Thiophene, and Thienopyridine Derivatives |
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| المؤلفون: | A. M. Atta, Ehab Abdel-Latif |
| المصدر: | Russian Journal of General Chemistry. 91:456-463 |
| بيانات النشر: | Pleiades Publishing Ltd, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 010405 organic chemistry, Chemistry, Chloroacetic acid, General Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, Chloroacetone, Pyridine, Thiophene, Moiety, Chloroacetamide, Semicarbazone, Malononitrile |
| الوصف: | New 4-acetyl-5-anilino-N-arylthiophene-2-carboxamide derivatives have been synthesized by reaction of 2-acetyl-3-oxo-N-phenylbutanethioamide with three different chloroacetamide reagents. The synthesized thiophenes have been used as precursors in preparation of various thiazole-thiophene hybrids via their condensation with thiosemicarbazide and following treatment of the corresponding thiosemicarbazone with chloroacetone and/or chloroacetic acid. The reaction of 4-acetyl-5-anilinothiophenes with DMF–DMA or malononitrile is the synthetic route to the targeted thieno[2,3-b]pyridine derivatives. Molecular structures of the synthesized compounds have been determined on the basis of IR, 1H and 13C NMR, and mass spectra. The synthesized thiophene-based compounds have been tested for in vitro cytotoxicity by the MTT assay using 5-flourouracil as a reference drug. Thiophene-2-carboxamide derivatives exhibit good inhibitory activity against four cell lines, especially those products that contain thiazolidinone ring or thiosemicarbazide moiety in their structures. |
| تدمد: | 1608-3350 1070-3632 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::a1ea86582c61df21fea681350cb921b8 https://doi.org/10.1134/s1070363221030154 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........a1ea86582c61df21fea681350cb921b8 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 16083350 10703632 |
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