Two ruthenium polypyridyl complexes functionalized with thiophen: synthesis and antibacterial activity against Staphylococcus aureus
| العنوان: | Two ruthenium polypyridyl complexes functionalized with thiophen: synthesis and antibacterial activity against Staphylococcus aureus |
|---|---|
| المؤلفون: | Jintao Wang, Guangbin Jiang, Xuemin Duan, Yanshi Xiong, Xiaoli Lin, Xiangwen Liao, Guijuan Jiang, Zhouyuji Liao, Jihong Shen |
| المصدر: | New Journal of Chemistry. 44:17215-17221 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0303 health sciences, medicine.drug_class, Phenanthroline, Aminoglycoside, Antibiotics, chemistry.chemical_element, Kanamycin, 02 engineering and technology, General Chemistry, 021001 nanoscience & nanotechnology, Antimicrobial, medicine.disease_cause, Medicinal chemistry, Catalysis, Ruthenium, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Staphylococcus aureus, Materials Chemistry, medicine, 0210 nano-technology, Antibacterial activity, 030304 developmental biology, medicine.drug |
| الوصف: | Two ruthenium polypyridyl complexes: [Ru(dmb)2(ETPIP)](ClO4)2 (Ru(II)-1) and [Ru(phen)2(ETPIP)](ClO4)2 (Ru(II)-2) (dmb = 4,4′-dimethyl-2,2′-bipyridine, phen = 1,10-phenanthroline, ETPIP = 2-(4-(thiophen-2-ylethynyl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline), have been synthesized and characterized. Their antimicrobial activities against S. aureus were assessed. Both the complexes Ru(II)-1, and Ru(II)-2 show meaningful activity against Staphylococcus aureus and the lead complex of this set, Ru(II)-2 (MIC = 0.025 mg mL−1), was further tested against biofilms. Given the fact that S. aureus could easily develop resistance to common antimicrobials, we also investigated whether bacteria can easily develop resistance to Ru(II)-2. The result demonstrated that S. aureus did not easily develop resistance to the ruthenium complexes. In addition, the synergism between Ru(II)-2 and common antibiotics against S. aureus was also investigated using the checkerboard method. Interestingly, Ru(II)-2 could increase the susceptibility of S. aureus to the aminoglycoside antibiotic (kanamycin). Finally, a possible mechanism of the observed synergetic effects was investigated by real-time PCR. All in all, these results confirmed that ruthenium complexes have good antimicrobial activity against Staphylococcus aureus. |
| تدمد: | 1369-9261 1144-0546 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::a2cc1e7d9b45f3bf073921b44eb4d2ec https://doi.org/10.1039/d0nj02944k |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........a2cc1e7d9b45f3bf073921b44eb4d2ec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13699261 11440546 |
|---|