Abstract P5-07-04: Aurora kinase regulates PKC-mediated MMP-9 expression and invasion in MCF-7 breast cancer cells
| العنوان: | Abstract P5-07-04: Aurora kinase regulates PKC-mediated MMP-9 expression and invasion in MCF-7 breast cancer cells |
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| المؤلفون: | SJ Lee, HJ Youn, YR Lee, JS Kim, EM Noh, B-M Hwang, SH Jung |
| المصدر: | Cancer Research. 72:P5-07 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Cancer Research, Cell signaling, Aurora kinase, Oncology, Kinase, Chemistry, Aurora inhibitor, Cancer research, Aurora Kinase A, Signal transduction, Protein kinase A, Protein kinase C |
| الوصف: | Aurora kinase is a novel family of serine/threonine kinases. Elevated expression of aurora kinase A and B is observed in many tumor cells, and dysregulation of aurora kinase has been linked to tumorigenesis. Therefore, a number of studies focused in their oncogene activities as anti-tumor targets. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix (ECM) and it is important process for breast cancer cell invasion. MMP-9 can be stimulated by activation of various cellular signaling pathways including protein kinase C (PKC), and mitogen-activated protein kinase (MAPKs), activator protein-1 (AP-1) and nuclear factor-kappaB (NF-κB) signaling pathways. Here, we show that 12-O-tetradecanoylphorbol-13-acetate (TPA), a directly PKC activator stimulation resulted in an up-regulation and phosphorlyation of aurora kinases in MCF-7 breast cancer cells. Also, Results showed that inhibition of the aurora kinases suppressed TPA-induced MMP-9 secretion/expression and cell invasion through suppression of NF-κB, AP-1, and MAPKs in MCF-7 breast cancer cell. In conclusion, this study provides new insight into the novel role of aurora kinase for expression of MMP-9 by TPA and regulation of aurora kinase by TPA through MAPKs signaling pathway. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P5-07-04. |
| تدمد: | 1538-7445 0008-5472 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::a2ff95c94cf905cd6cd1d4ab49448848 https://doi.org/10.1158/0008-5472.sabcs12-p5-07-04 |
| رقم الأكسشن: | edsair.doi...........a2ff95c94cf905cd6cd1d4ab49448848 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387445 00085472 |
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