FRI0447 FIRST COMPREHENSIVE LONG-TERM ASSESSMENT OF MUSCULOSKELETAL CONSEQUENCES AMONG EBOLA SURVIVORS
| العنوان: | FRI0447 FIRST COMPREHENSIVE LONG-TERM ASSESSMENT OF MUSCULOSKELETAL CONSEQUENCES AMONG EBOLA SURVIVORS |
|---|---|
| المؤلفون: | M. S. Sow, Yves-Marie Pers, Bernard Taverne, M. D. Sall, M. Barry, Eric Delaporte, Jean-François Etard, A. Dubois, Alpha Kabinet Keita, Laura March, A. Toure, T. A. Barry |
| المصدر: | Annals of the Rheumatic Diseases. 79:821.1-821 |
| بيانات النشر: | BMJ, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | myalgia, education.field_of_study, Pediatrics, medicine.medical_specialty, Ebola virus, business.industry, Immunology, Population, Outbreak, Disease, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Rheumatology, Median time, Cohort, medicine, Immunology and Allergy, Risk factor, medicine.symptom, education, business |
| الوصف: | Background:The tremendous size of the 2013-2016 West African outbreak of Ebola virus disease (EVD) resulted in a sizeable population of survivors, many reporting short-term sequelae such as arthralgia and myalgia.Objectives:We aimed to report a detailed and long-term description of patients’ musculoskeletal (MS) symptoms.Methods:We performed a cross-sectional study following systematic rheumatological screening of patients included in the Postebogui cohort (Conakry district). We used regression models to establish the magnitude of EVD as a risk factor for developing chronic MS pain by comparison with a control cohort and to establish risk factors for developing MS pain among survivors.Results:The study included 313 patients (55.6% female), with a median age of 28.2 years (IQR 21-37), and a median time from ETC discharge to rheumatological visit of 26.2 months (IQR 23-30). Chronic MS pain was reported in 216 (69%) patients, and was predominantly mechanical (48%). Enthesis and painful peripheral joints were largely involved (91%) with symmetrical distribution. Previous Ebola infection was a major risk factor for chronic MS pain (aOR, 6.662 [95% CI, 4.522–9.921]). Among survivors, increasing age (OR 1.14, 95% CI 1.08-1.22) and female gender (OR 3.58, 95% CI 1.22-11.80) were both associated with persistent MS pain, while myalgia experienced during the acute phase of EVD appeared protective (OR 0.14, 95% CI 0.04-0.42).Conclusion:Our study provides the most accurate long-term description of MS disorders among Ebola survivors. Joint and muscle pain sequelae are frequent and require specialized care.Disclosure of Interests:None declared |
| تدمد: | 1468-2060 0003-4967 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::a4e7989fcf10ea68a102a140140dfd93 https://doi.org/10.1136/annrheumdis-2020-eular.1218 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........a4e7989fcf10ea68a102a140140dfd93 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14682060 00034967 |
|---|