Base of skull recurrences after treatment of salivary gland cancer with perineural invasion reduced by postoperative radiotherapy
| العنوان: | Base of skull recurrences after treatment of salivary gland cancer with perineural invasion reduced by postoperative radiotherapy |
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| المؤلفون: | Nancy Y. Lee, Joaquin Garcia, P. Granchi, M.K. Bucci, A.M. Chen |
| المصدر: | Clinical Otolaryngology. 34:539-545 |
| بيانات النشر: | Wiley, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | medicine.medical_specialty, Base of skull, business.industry, Incidence (epidemiology), Perineural invasion, Retrospective cohort study, medicine.disease, Surgery, Skull, medicine.anatomical_structure, Skull Base Neoplasm, Otorhinolaryngology, Salivary gland cancer, medicine, Carcinoma, business |
| الوصف: | Objectives: To determine the effect of postoperative radiation therapy for salivary gland carcinomas in the presence of microscopic perineural invasion. Design and setting: Retrospective review at an academic tertiary center. Participants: One hundred and forty patients with pathological evidence of perineural invasion at the time of initial surgery for salivary gland carcinomas were analysed. Sixteen patients (11%) had major (named) nerve involvement. Ninety-four patients (67%) received postoperative radiation therapy to the primary site, and the portal films of 65 of these patients were available for review. Main outcome measures: The incidence of skull base recurrences among patients treated by surgery with or without postoperative radiation therapy. Results: Ten patients experienced skull base recurrences. T4 disease and the omission of postoperative radiation therapy were identified as significant predictors of skull base recurrence. Postoperative radiation therapy reduced the actuarial probability of skull base recurrence from 15% to 5% (P = 0.03). The crude rates of skull base recurrence were 6% (2/35) and 10% (3/30), respectively, for patients whose skull base were and were not confirmed to be encompassed in the irradiation field. The 5-year overall survival for patients who experienced a skull base recurrence was 19% compared to 91% for those who did not (P |
| تدمد: | 1749-4486 1749-4478 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::a60fff829cb292a48446ee60ebe62e29 https://doi.org/10.1111/j.1749-4486.2009.02036.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........a60fff829cb292a48446ee60ebe62e29 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17494486 17494478 |
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