Two Small Molecules, ZCL278 and AZA197 Show Promise in Influencing Protein Interactions Involving the Ras-Related Protein Cell division cycle 42 [Cdc42] to Modulate Its Oncogenic Potential
| العنوان: | Two Small Molecules, ZCL278 and AZA197 Show Promise in Influencing Protein Interactions Involving the Ras-Related Protein Cell division cycle 42 [Cdc42] to Modulate Its Oncogenic Potential |
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| المؤلفون: | Djamali Muhoza, Paul D. Adams |
| المصدر: | Open Journal of Biophysics. :71-81 |
| بيانات النشر: | Scientific Research Publishing, Inc., 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Subfamily, Druggability, macromolecular substances, CDC42, Biology, Small molecule, Protein–protein interaction, Cell biology, Cell division cycle, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis |
| الوصف: | Cdc42 is a member of the Rho subfamily of Ras-related proteins, which were among the first oncogenic proteins to be identified as playing a sig-nificant role in a variety of cellular events [Barbacaid, 1987, Ann. Rev. Biochem]. Equally important, Protein-Protein Interactions [PPIs] involving Cdc42 continue to highlight the role of Ras-related proteins’ relevance to cancer. As these proteins have been considered incapable of being “druggable”, due to a perceived lack of binding surface[s] that are amenable to small molecule targeting, there remains limited development of therapies to tackle diseased states caused by Cdc42-stimulated hyperactivity. Thusly, it has become important to characterize molecular details, including dynamics, of PPIs involving Cdc42 that may lend themselves as potential targets for therapeutic approaches. Recently, two small molecules, ZCL278 and AZA197, have shown promise in directly targeting Cdc42 to influence PPIs that are capable of causing Cdc42-stimulated abnormal signaling. In this editorial, we highlight recent studies that show case how these two small molecules may influence Cdc42-protein interactions. |
| تدمد: | 2164-5396 2164-5388 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::a7e44b2e31990459c1daae0cc1be35a9 https://doi.org/10.4236/ojbiphy.2017.73006 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........a7e44b2e31990459c1daae0cc1be35a9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21645396 21645388 |
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