Systematic Optimization of a Robust Telescoped Process for a BTK Inhibitor with Atropisomer Control by High-Throughput Experimentation, Design of Experiments, and Linear Regression
| العنوان: | Systematic Optimization of a Robust Telescoped Process for a BTK Inhibitor with Atropisomer Control by High-Throughput Experimentation, Design of Experiments, and Linear Regression |
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| المؤلفون: | Kishta Katipally, Federico Lora Gonzalez, Jason M. Stevens, Thomas M. Razler, Steven R. Wisniewski, Victor W. Rosso, Brendan Mack |
| المصدر: | Organic Process Research & Development. 23:1143-1151 |
| بيانات النشر: | American Chemical Society (ACS), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Atropisomer, biology, 010405 organic chemistry, Computer science, Design of experiments, Organic Chemistry, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, immune system diseases, Control theory, hemic and lymphatic diseases, Scientific method, Linear regression, biology.protein, Bruton's tyrosine kinase, Physical and Theoretical Chemistry, Throughput (business) |
| الوصف: | The development of a telescoped process for the API step in the route to a reversible inhibitor of BTK is reported. Although a robust and effective reaction and crystallization was previously imple... |
| تدمد: | 1520-586X 1083-6160 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::a9472c5948819f3995a2fc4d67d29d19 https://doi.org/10.1021/acs.oprd.8b00398 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........a9472c5948819f3995a2fc4d67d29d19 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 1520586X 10836160 |
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