Ex vivo/In vitro Interaction between ASA, Clopidogrel and GPIIb/IIIa-Inhibitors
| العنوان: | Ex vivo/In vitro Interaction between ASA, Clopidogrel and GPIIb/IIIa-Inhibitors |
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| المؤلفون: | Dagmar Westrup, C. M. Kirchmaier, Jochen Graff, Ute Klinkhardt, R. Mahnel, Hans-Klaus Breddin, S. Harder |
| المصدر: | Hämostaseologie. 19:112-114 |
| بيانات النشر: | Georg Thieme Verlag KG, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | GpIIb/IIIa, surgical procedures, operative, Chemistry, medicine, cardiovascular diseases, Hematology, Pharmacology, Clopidogrel, Ex vivo, In vitro, circulatory and respiratory physiology, medicine.drug |
| الوصف: | SummaryWe report on an in vivo interaction study between aspirin (ASA) and Clopidogrel in healthy male volunteers and on an in-vitro interaction of abciximab and the peptidomimetic GPIIb/IIIa-inhibitor SR121566A with blood from subjects of the in vivo-study. Ten healthy male volunteers were randomly assigned to two groups (N = 5). Group 1 started with ASA and group 2 with Clopidogrel. From day 4 to 8 subjects of both groups received combined treatment with ASA and Clopidogrel. Blood from volunteers was spiked with abciximab or SR121566A. Inhibitory effects of ASA and Clopidogrel on collagen- or ADP-induced platelet aggregation were not enhanced by the combination of both drugs. TRAP-induced fibrinogen binding was reduced under ASA to 69% (n.s.), and to 63% under Clopidogrel or Clopidogrel + ASA. CD62-expression was reduced to 66% by Clopidogrel (p |
| تدمد: | 2567-5761 0720-9355 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::aa013e8bb2dd266d4c13f3062831fd52 https://doi.org/10.1055/s-0038-1660392 |
| رقم الأكسشن: | edsair.doi...........aa013e8bb2dd266d4c13f3062831fd52 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25675761 07209355 |
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