Therapeutic Equivalence of a Novel HFA134a-Containing Metered-Dose Inhaler and the Conventional CFC Inhaler (Berodual®) for the Delivery of a Fixed Combination of Fenoterol/ Ipratropium Bromide
| العنوان: | Therapeutic Equivalence of a Novel HFA134a-Containing Metered-Dose Inhaler and the Conventional CFC Inhaler (Berodual®) for the Delivery of a Fixed Combination of Fenoterol/ Ipratropium Bromide |
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| المؤلفون: | Frans D.M. Wald, Louis P.M. Greefhorst, P.J.G. Cornelissen, Francis P.V. Maesen, J.J. Smeets |
| المصدر: | Respiration. 64:273-280 |
| بيانات النشر: | S. Karger AG, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Inhalation, business.industry, medicine.drug_class, Inhaler, respiratory system, Ipratropium bromide, Pharmacology, Crossover study, Metered-dose inhaler, Bronchodilatation, Bronchodilator, Anesthesia, Medicine, business, Fenoterol, medicine.drug |
| الوصف: | The efficacy and safety of a novel fenoterol/ipratropium bromide metered-dose inhaler (MDI) formulated with a non-chlorinated propellant, HFA134a, has been compared with placebo and the conventional chlorofluorocarbon (CFC)-containing fenoterol/ipratropium bromide inhaler (Berodual) in asthmatic patients. Fifty-two patients were enrolled in two centres. The fenoterol/ ipratropium bromide treatment produced significantly (P or = 15% in baseline FEV1 or needed rescue medication within 30 min after inhalation of the test drug. No paradoxical bronchoconstriction was observed as measured by sGaw. The two inhaler formulations were well tolerated. A taste-related complaint, lasting for a few minutes after inhalation, was reported by a higher proportion of patients who inhaled the HFA134a formulation, mainly by patients selected in one of the two centres. In conclusion, a dose of 100 micrograms fenoterol/40 micrograms ipratropium bromide inhaled from a MDI containing HFA134a propellant is safe and provides effective bronchodilatation of equivalent degree, onset and duration of action to the same dose from the conventional CFC formulation. |
| تدمد: | 1423-0356 0025-7931 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::ab41782913e44b4f4571e12dc8df85a3 https://doi.org/10.1159/000196686 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........ab41782913e44b4f4571e12dc8df85a3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230356 00257931 |
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