Exploring hydrophobic diastereomeric 2,6-anhydro-glycoheptitols for their enzymatic polymerization with PEG: towards delivery applications
| العنوان: | Exploring hydrophobic diastereomeric 2,6-anhydro-glycoheptitols for their enzymatic polymerization with PEG: towards delivery applications |
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| المؤلفون: | Satyanarayan Deep, Ekta Kohli, Rainer Haag, Sumati Bhatia, Ashok K. Prasad, Vinod Khatri, Nihar Nalini Senapati |
| المصدر: | New Journal of Chemistry. 44:15369-15375 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Aqueous solution, Nile red, General Chemistry, Polymer, Degree of polymerization, Micelle, Catalysis, chemistry.chemical_compound, chemistry, Polymerization, Polymer chemistry, PEG ratio, Materials Chemistry, Copolymer |
| الوصف: | Two sugar PEG-based amphiphilic copolymers have been synthesized by Novozym®-435-catalyzed greener solvent free transesterification reaction of diastereomeric 2,6-anhydro-3,4,5-tri-O-benzyl-glucoheptitol and 2,6-anhydro-3,4,5-tri-O-benzyl-mannoheptitol with PEG-1000 diethyl ester in 80 and 76% yields, respectively. It has been observed that the configurational change at one of the carbons of diastereomeric 2,6-anhydro-heptitols has significant bearing on the degree of polymerization and characteristics of the synthesized polymers. Thus, the study of physico-chemical characteristics of synthesized anhydroglucoheptitol- and anhydromannoheptitol-PEG copolymers revealed that their aqueous solution forms spherical micelles of hydrodynamic diameters 11.2 and 6.4 nm, respectively. Micelles derived from both the amphiphilic copolymers have the potential to solubilize the hydrophobic dye, Nile red. Furthermore, a fluorescence microscopy study revealed that Nile red encapsulated micelles of synthesized amphiphilic copolymers uniformly internalized in A549 cells and thus can be used as a cargo carrier in biological systems. The viability of A549 cells was found to be very high even at a concentration of 500 μg mL−1 of copolymer indicating that they are cyto-compatible. |
| تدمد: | 1369-9261 1144-0546 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::ab4c56b1ca7396586369883d68b14bfc https://doi.org/10.1039/d0nj02642e |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........ab4c56b1ca7396586369883d68b14bfc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13699261 11440546 |
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