Effect of drug aceclofenac on physicochemical properties of mixed micellar systems
| العنوان: | Effect of drug aceclofenac on physicochemical properties of mixed micellar systems |
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| المؤلفون: | B. Sheelarani, E. Paul Raj, R. G. Joshi, Sasmita Dash |
| المصدر: | SN Applied Sciences. 4 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | General Chemical Engineering, General Engineering, General Earth and Planetary Sciences, General Physics and Astronomy, General Materials Science, General Environmental Science |
| الوصف: | Abstract In this article, the effect of the drug aceclofenac (ACF) on the properties of three mixed micellar systems are studied. The three systems were pluronic L64 + F127 (nonionic-nonionic), pluronic L64 + CTAB (cetyltrimethyl ammonium bromide), (nonionic-cationic) and L64 + SDS (Sodium dodecyl sulphate), (nonionic-anionic) combinations. The physicochemical parameters were characterized by different techniques such as UV visible spectroscopy, FTIR, conductance, DLS, and SEM. The presence of ACF affected the nonionic-ionic mixed micelles more than the nonionic-nonionic group as evidenced by UV spectroscopy. From the DLS measurement, it was observed that ACF enhanced the size of the single micelle of pluronic L64 from 98 to 168 nm. The size of the cationic mixed micelle with ACF displayed 329 nm and the anionic mixed one showed 291 nm suggesting enhanced entrapment efficiency of their mixed micelle compared to the single micelles. The size was also reconfirmed by SEM analysis. From the conductivity measurements of the two nonionic-ionic micellar systems, the counter ion binding constant β, and the thermodynamic parameters ΔG, ΔH, and ΔS were determined. The negative value of ΔG infers spontaneous binding between ACF and ionic mixed micelles. Article highlights Ionic mixed micelles are more effective than nonionic pair. ACF has more spontaneous binding with anionic mixed micelle compared to cationic. The drug entrapment efficiency is better in mixed micelles than in single micelles. |
| تدمد: | 2523-3971 2523-3963 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::aba399b14f38ac90211092834aaf8fc3 https://doi.org/10.1007/s42452-022-05055-3 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........aba399b14f38ac90211092834aaf8fc3 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 25233971 25233963 |
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