18 F-Sodium Fluoride Positron Emission Tomography Activity Predicts the Development of New Coronary Artery Calcifications
| العنوان: | 18 F-Sodium Fluoride Positron Emission Tomography Activity Predicts the Development of New Coronary Artery Calcifications |
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| المؤلفون: | Michael Phillips, Gerald F. Watts, Sing Ching Lee, Roslyn J. Francis, Adil Rajwani, Jamie W Bellinge, Joshua R. Lewis, Carl Schultz |
| المصدر: | Arteriosclerosis, Thrombosis, and Vascular Biology. |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.diagnostic_test, business.industry, chemistry.chemical_element, 030204 cardiovascular system & hematology, Calcium, medicine.disease, Coronary Calcium Score, Coronary artery disease, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine.anatomical_structure, chemistry, Positron emission tomography, Diabetes mellitus, Internal medicine, Sodium fluoride, Disease risk, medicine, Cardiology, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business, Artery |
| الوصف: | Objective: The coronary calcium score (CCS) predicts cardiovascular disease risk in individuals with diabetes mellitus, and rate of progression of CCS is an additional and incremental marker of risk. 18 F-sodium fluoride positron emission tomography ( 18 F-NaF PET) detects early and active calcifications within the vasculature. We aimed to ascertain the relationship between 18 F-NaF PET activity and CCS progression in patients with diabetes mellitus. Approach and Results: We identified individuals between 50 and 80 years with diabetes mellitus and no history of clinical coronary artery disease. Those with a CCS ≥10 were invited to undergo 18 F-NaF PET scanning and then repeat CCS >2 years later. 18 F-NaF PET and CCS analysis were performed on a per-coronary and a per-patient level. We compared the proportion of CCS progressors in 18 F-NaF PET–positive versus 18 F-NaF PET–negative coronary arteries. Forty-one participants with 163 coronary arteries underwent follow-up CCS 2.8±0.5 years later. 18 F-NaF PET–positive coronary arteries (n=52) were more likely to be CCS progressors, compared with negative coronary arteries (n=111; 86.5% versus 52.3%, P 18 F-NaF PET–positive disease was an independent predictor of subsequent CCS progression (odds ratio, 2.92 [95% CI, 1.32–6.45], P =0.008). All subjects (100%, 15/15) with ≥2 18 F-NaF–positive coronary arteries progressed in CCS. Conclusions: In subjects with diabetes mellitus, 18 F-NaF PET positivity at baseline, independently predicted the progression of calcifications within the coronary arteries 2.8 years later. These findings suggest 18 F-NaF PET may be a promising technique for earlier identification of patients at higher risk of cardiovascular events. |
| تدمد: | 1524-4636 1079-5642 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::abd96176205a7f325f22d28a9726e208 https://doi.org/10.1161/atvbaha.120.315364 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........abd96176205a7f325f22d28a9726e208 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244636 10795642 |
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