Voiding Dysfunction in Mice With Experimental Autoimmune Encephalomyelitis: A Multiple Sclerosis-Like Disease
| العنوان: | Voiding Dysfunction in Mice With Experimental Autoimmune Encephalomyelitis: A Multiple Sclerosis-Like Disease |
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| المؤلفون: | Xavier Gamé, L. Even, Bernard Malavaud, O. Bouali, Mathieu Roumiguié, Olivier Cuvillier |
| المصدر: | World Journal of Nephrology and Urology. 5:4-10 |
| بيانات النشر: | Elmer Press, Inc., 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | medicine.medical_specialty, Pathology, business.industry, media_common.quotation_subject, Urinary system, Multiple sclerosis, Experimental autoimmune encephalomyelitis, 030232 urology & nephrology, Urology, Neurological disorder, medicine.disease, Urination, 03 medical and health sciences, 0302 clinical medicine, Overactive bladder, medicine, Bladder Disorder, business, 030217 neurology & neurosurgery, media_common, Upper urinary tract |
| الوصف: | Background: Multiple sclerosis (MS) is the most common disabling neurological disorder affecting young adults. Lower urinary tract dysfunction (LUTD) is common during the course of MS and is responsible for an organic impact on the upper urinary tract and for impaired quality of life. Experimental autoimmune encephalomyelitis (EAE), an animal model of MS, is characterized in mice by paralysis of the tail and hind limbs progressing to paraplegia, but urinary parameters and voiding behavior are not well understood. We aimed to study micturition behavior of both healthy and EAE mice to determine changes induced by EAE. Methods: Bladder function study included micturition behavior and filling cystometry. Results: EAE mice developed profound bladder dysfunction characterized by a decrease in urine volume per micturition (138.8 ± 20 vs. 213 ± 17.5 µL, P = 0.018), significantly more frequent postvoid residual urine (30% vs. 61%, P = 0.0496), and increased postvoid residual volume (260 ± 15 vs. 197.5 ± 12 µL, P = 0.045). Cystometric analysis showed significantly more frequent detrusor overactivity (69% vs. 1%, P < 0.0001). Conclusions: Our study, characterizing bladder dysfunction in EAE mice by clinical and cystometric examination, showed that dysfunction was similar to neurological bladder disorders found in human multiple sclerosis and makes this model promising to assess new compounds. World J Nephrol Urol. 2016;5(1):4-10 doi: http://dx.doi.org/10.14740/wjnu245w |
| تدمد: | 1927-1247 1927-1239 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::adb6c93eedf972ba0a6236bf5bea9df2 https://doi.org/10.14740/wjnu245w |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........adb6c93eedf972ba0a6236bf5bea9df2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19271247 19271239 |
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