EP300 and CREBBP histone acetyltransferases modulate individuals’ episodic memory
| العنوان: | EP300 and CREBBP histone acetyltransferases modulate individuals’ episodic memory |
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| المؤلفون: | Ding Li, Junlin Li, Meijie Zhang, Kejin Zhang, Xiaocai Gao, Fuchang Zhang |
| المصدر: | Biologia. 75:1409-1413 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0106 biological sciences, 0301 basic medicine, Histone Acetyltransferases, Cognitive aging, biology, Individual difference, Cell Biology, Plant Science, 01 natural sciences, Biochemistry, 03 medical and health sciences, 030104 developmental biology, Histone, Genetics, biology.protein, Semantic memory, Animal Science and Zoology, EP300, Psychology, Molecular Biology, Neuroscience, Episodic memory, Declarative memory, Ecology, Evolution, Behavior and Systematics, 010606 plant biology & botany |
| الوصف: | Declarative memory, including episodic and semantic memories, enables us to connect the present things with the past experiences. E1A binding protein p300 (EP300) and cAMP response element binding-binding protein (CREBBP), two important histone acetyltransferases (HATs) of KAT3 family, are involved in the development of cognitive aging such as the decreasing in episodic memory. However, no evidence suggested their potential roles in individual difference in declarative memories of youth. In the present study, we investigated whether EP300 and CREBBP genes modulated individual difference in declarative memory among youth subjects by using Remember (R)/Know (K) paradigm. The results showed that rs4822004 in EP300 modulated R responses (episodic memory) as controlling K responses (β = 0.076, R2 = 0.385, F = 180.322, p = 0.020). Moreover, we also found that rs130032 in CREBBP also modulated the performance of R responses after controlling K responses (β = 0.068, R2 = 0.384, F = 178.483, p = 0.038). The study suggests that EP300 and CREBBP genes contribute to the individuals’ difference in episodic memory, which provides evidence on the roles of histone acetylation activity in human declarative memory. |
| تدمد: | 1336-9563 0006-3088 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::ae69b13f55aad3bf5180866c1e4e924b https://doi.org/10.2478/s11756-020-00431-z |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........ae69b13f55aad3bf5180866c1e4e924b |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 13369563 00063088 |
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