Pathophysiological adaptations of resistance arteries in rat offspring exposed in utero to maternal obesity is associated with sex-specific epigenetic alterations
| العنوان: | Pathophysiological adaptations of resistance arteries in rat offspring exposed in utero to maternal obesity is associated with sex-specific epigenetic alterations |
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| المؤلفون: | Lily Paillat, Laurent Loufrani, Abdallah Dib, Tamas Aranyi, Ábel Fóthi, Françoise Schmitt, Abigaëlle Guillot, Céline Fassot, Cyrielle Payen, Daniel Henrion, Mathilde Munier, Jennifer Bourreau |
| المصدر: | International Journal of Obesity. 45:1074-1085 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Fetus, medicine.medical_specialty, Nutrition and Dietetics, Offspring, business.industry, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, Medicine (miscellaneous), Adipose tissue, 030209 endocrinology & metabolism, Vasodilation, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, medicine.anatomical_structure, In utero, Internal medicine, medicine, 030212 general & internal medicine, Epigenetics, business, Mesenteric arteries |
| الوصف: | Background/objectives Maternal obesity impacts vascular functions linked to metabolic disorders in offspring, leading to cardiovascular diseases during adulthood. Even if the relation between prenatal conditioning of cardiovascular diseases by maternal obesity and vascular function begins to be documented, little is known about resistance arteries. They are of particular interest because of their specific role in the regulation of local blood flow. Then our study aims to determine if maternal obesity can directly program fetal vascular dysfunction of resistance arteries, independently of metabolic disorders. Methods With a model of rats exposed in utero to mild maternal diet-induced obesity (OMO), we investigated third-order mesenteric arteries of 4-month old rats in absence of metabolic disorders. The methylation profile of these vessels was determined by reduced representation bisulfite sequencing (RRBS). Vascular structure and reactivity were investigated using histomorphometry analysis and wire-myography. The metabolic function was evaluated by insulin and glucose tolerance tests, plasma lipid profile, and adipose tissue analysis. Results At 4 months of age, small mesenteric arteries of OMO presented specific epigenetic modulations of matrix metalloproteinases (MMPs), collagens, and potassium channels genes in association with an outward remodeling and perturbations in the endothelium-dependent vasodilation pathways (greater contribution of EDHFs pathway in OMO males compared to control rats, and greater implication of PGI2 in OMO females compared to control rats). These vascular modifications were detected in absence of metabolic disorders. Conclusions Our study reports a specific methylation profile of resistance arteries associated with vascular remodeling and vasodilation balance perturbations in offspring exposed in utero to maternal obesity, in absence of metabolic dysfunctions. |
| تدمد: | 1476-5497 0307-0565 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::af54f97744b567fbdcb39a9a9cfbac8a https://doi.org/10.1038/s41366-021-00777-7 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........af54f97744b567fbdcb39a9a9cfbac8a |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14765497 03070565 |
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